Speaker Profile

For Pharmacogenomics: Advanced the use of pharmacogenetic testing, preemptively, resulting in improvements in medication safety and efficacy for patients

Pharm.D., Ph.D. BCPS, FCCP, Clinical Pharmacogenetics Implementation Consortium (CPIC) Co-PI and Director St. Jude Children’s Research Hospital

The Clinical Pharmacogenetics Implementation Consortium (CPIC®) is an international consortium of volunteers and a small, dedicated staff who are interested in facilitating the use of pharmacogenetic tests results for patient care. One barrier to implementation of pharmacogenetic testing in the clinic is the difficulty in translating genetic laboratory test results into actionable prescribing decisions for affected drugs. CPIC’s goal is to address this barrier to clinical implementation of pharmacogenetic tests by creating, curating, and posting freely available, peer-reviewed, evidence-based, updatable, and detailed gene/drug clinical practice guidelines publications. To date, CPIC has published 26 gene-based clinical guidelines. CPIC guidelines follow standardized formats, include systematic grading of evidence and clinical recommendations, use standardized terminology, are peer-reviewed, and are published in a leading journal (in partnership with Clinical Pharmacology and Therapeutics) with simultaneous posting to cpicpgx.org, where they are regularly updated. CPIC started as a shared project between PharmGKB, and the Pharmacogenomics Research Network (PGRN) in 2009. CPIC guidelines are indexed in PubMed as clinical guidelines, endorsed by ASHP and ASCPT, and referenced in ClinGen and PharmGKB. Dr. Caudle oversees all Clinical Pharmacogenomic implementation Consortium-related projects and the CPIC guideline development process including the coordination of the guideline-writing committees, the guideline evidence reviews, and the writing of the guideline manuscript and supplement. Dr. Caudle is also involved in clinical implementation of pharmacogenetics at St. Jude Children’s Research Hospital. She has published over 50 manuscripts in the area of pharmacogenomics. Dr. Caudle received a bachelor of science from Middle Tennessee State University and her Pharm D and PhD in Pharmaceutical Sciences from University of Tennessee Health Science Center where she is currently an affiliate Asst. Professor. She has completed an ASHP-accredited PGY2 residency at Le Bonheur Children’s Hospital and is a board‐certified Pharmacotherapy Specialist.

CPIC: Advancing Pharmacogenomics into Routine Clinical Practice
Over the past 12 years, the Clinical Pharmacogenetics Implementation Consortium (CPIC) has provided resources to facilitate the implementation of pharmacogenetics into routine clinical practice. To date, CPIC has published 26 gene-based clinical guidelines covering 25 genes and over 90 drugs. This talk will explore the past, present and future of CPIC.