Session Abstract – PMWC 2022 Silicon Valley

 Session Chair Profile

Ph.D., VP, Research and Early Development, Graphite Bio

Biography
Dr. Vanessa Soros is VP of Research and Early Development of Graphite Bio, a gene editing and cell therapy company, leading discovery research and development efforts. Prior to Graphite Bio, Dr. Soros was Sr. Director of Antibody Development and Engineering at Tizona Therapeutics, where her work led to several first-in-class antibody therapeutics to novel immune-oncology targets. Prior to Tizona, Vanessa was a lead scientist in the development of discovery platforms and screening systems for novel biologics at both Catalyst Biosciences and Sea Lane Biotechnologies. Vanessa obtained her Ph.D. from the University of Toronto in Molecular Biology and Medical Genetics and pursued her postdoctoral studies at the Gladstone Institute of Virology and Immunology, at the University of California, San Francisco.


 Speaker Profile

M.D., Chief Medical Officer, Beam Therapeutics

Biography
Amy Simon, M.D. is Chief Medical Officer of Beam Pharmaceuticals. Dr. Simon brings has over 20 years of clinical experience, serving in roles as a physician-scientist in academia and the biotechnology industry. Dr. Simon joined Beam in March 2021 from Alnylam Pharmaceuticals, where she spent over a decade in various roles with increasing responsibility for the clinical development of RNAi-based medicines, most recently serving as vice president, clinical development. During her tenure at Alnylam, she led the successful execution of clinical programs from natural history studies to Phase 1 through Phase 4 studies, regulatory interactions with both U.S. and ex-U.S. authorities, and drug approvals in the U.S. and EU. Dr. Simon was the lead clinician developing GIVLAARI® (givosiran) for patients with acute hepatic porphyria, which was approved by the Food and Drug Administration in 2019. Prior to entering the biotech industry, Dr. Simon worked in academia at Tufts University, serving as a professor and a director of the Asthma Center in the Pulmonary and Critical Care Division at Tufts University School of Medicine and as a professor at Tufts Graduate School of Biomedical Science where her laboratory conducted basic science research on asthma. She began her career in clinical practice, training as a resident in internal medicine and as a fellow in pulmonary and critical care medicine at Tufts Medical Center.  Dr. Simon holds a B.A. in history and science from Harvard University, and an M.D. from Tufts University School of Medicine.


 Speaker Profile

M.D., Ph.D., Executive Chairman, Poseida Therapeutics

Biography
Eric Ostertag, M.D., Ph.D., is founder and Executive Chairman of Poseida Therapeutics, Inc., a clinical-stage biopharmaceutical company utilizing proprietary genetic engineering platform technologies to create cell and gene therapeutics with the capacity to cure. A pioneer in cell and gene therapies, Dr. Ostertag was the first graduate of the Gene Therapy Program at the University of Pennsylvania School of Medicine. He received both his Ph.D. in molecular biology and his M.D. from the University of Pennsylvania School of Medicine and his B.S. in genetics from the University of Wisconsin-Madison. From there he went on to found and lead multiple biotechnology companies, including Poseida Therapeutics in 2015 and Transposagen Biopharmaceuticals, Inc., Poseida’s parent company and an early leader in the development of gene-engineering technologies. Dr. Ostertag served as Poseida’s CEO for seven years before transitioning to the role of Executive Chairman in February 2022.


 Speaker Profile

M.D., Ph.D., VP, Clinical Development, Intellia Therapeutics

Biography
Mark McKee, M.D leads the medical sciences group within Clinical Development at Intellia therapeutics. In addition, he has served as the head of program teams for several of Intellia’s lead assets during his tenure at the company. Prior to joining Intellia, Mark was in the Oncology Clinical Development group at AbbVie and was a physician and researcher at the University of Chicago. He received his Bachelor of Science and Medical Degrees from Northwestern University and completed his clinical training at Harvard Beth Israel Deaconess medical Center and the National Institutes of Health.


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