Speaker Profile

Ph.D., Associate Director, Discovery & Translational Sciences, Metabolon, Inc.

Dr. Michelotti is a biochemist with special expertise in the analysis of large metabolomics and gene expression datasets. As principle investigator of a translational research laboratory at Duke University for 15 years, Dr. Michelotti successfully attracted both federal and pharmaceutical grants. His laboratory contributed to the identification of novel G protein coupled receptor-mediated stress-response cascades that contribute to de-regulated epithelial growth responses. Collectively, this work resulted in the publication of over 70 peer reviewed publications, resulting in an h-index of 31. Dr. Michelotti joined Metabolon in 2015 to apply his expertise in signal transduction, cancer biology, and metabolism to assist investigators in the successful design and execution, and analysis of large metabolomic data sets to provide biological insight into complex human pathologies.

 Session Abstract – PMWC Silicon Valley

Understanding mechanism of action and translating microbiome science into commercially viable therapeutics remains the biggest challenge in this emerging field. With that said, pharma and biotech across many different therapeutic indications and modalities are united in this global effort to bring novel microbiome-based therapies and diagnostics into the clinical domain. This session will include some of the most impactful and promising areas of the microbiome field:

  • Fecal Microbiota Transplantation (FMT)
    To date, FMT, or the transfer of donor feces containing gut microbiota from a healthy individual to restore microbial diversity in patients, has been used for the treatment of patients with chronic gastrointestinal infections and inflammatory bowel diseases. Now there is great interest in its therapeutic potential for other applications. This session will explore the use of FMT for IBD, IBS, metabolic syndrome, neurodevelopmental disorders, and autoimmune diseases, among others.
    - Tor Savidge, Baylor College of Medicine
  • Microbiome Profiling through “Omics” Methods
    Advances in sequencing and analysis tools have provided unprecedented insight and resolution into the microbiome and is enabling researchers and clinicians to monitor shifts in the microbiome-- from taxonomic profiling to metabolomics and proteomics. This session will uncover some of the latest and most advanced tools for microbiome analysis and where the current trends are taking the industry next.
    - Sandrine M. Miller-Montgomery, UCSD
    - Manoj Dadlani, COSMOSID
    - Martha Carlin, The BioCollective
    - Lihi Segal, DayTwo
    - Gregory Michelotti, Metabolon
    - Sanjay Joshi, Dell EMC
    - Morten Isaksen, Bio-Me AS
  • The Skin Microbiome
    Human skin is populated by diverse bacteria and there is increasing evidence that resident bacteria play a key role initiating immune responses in numerous diseases. This session will look at techniques to modulate the skin microbiome composition as a therapeutic option in diseases affecting the skin such as psoriasis and acne vulgaris.
    - Mark S. Wilson, MatriSys Bioscience
    - Larry Weiss, Persona Biome, Inc.
  • Microbiome Modulation by Diet
    Advances in microbiome research are spurring the development of new therapeutics for a variety of diseases. This session will explore recent discoveries in gut microbiome interventions for promoting human health and combating disease. These approaches include microbiome modulation or direct impact on the host through nutritional intervention, either by prebiotics or by individualized diets.
    - Colleen Cutcliffe, Pendulum Therapeutics
  • Gastroenterology & the Microbiome
    This session will take the perspective of the clinician, as the microbiome approaches the clinic and will focus on how novel microbiome science can be communicated to classically trained gastroenterologists and other clinicians, in order to prepare them to bring these practices to patients.
    - Haroldo Magarinos, BioVital Health
  • Regulatory Affairs & Standardization
    Uniform, rigorous, and unbiased experimental and regulatory approaches, similar to the careful and stringent testing and approval processes practiced in other human interventions, will allow the safe and efficacious long-term integration of microbiome-based therapies into the treatment of a variety of different diseases. This session will address the standardization work done to date and what the next big challenges are to be addressed.
    - Scott A. Jackson, NIST
  • Pre-Clinical & Clinical Development
    A new and exciting aspect of mirobiome research focuses on personalization of interventions, as well as harnessing the inherent individualized variability in microbiomes and other physiological features. This session will aim to provide insight into best practices and the pitfalls to avoid.
    - Nikole Kimes, Siolta Therapeutics
    - Mary Conrad, Axial Therapeutics
    - Jackie Papkoff, Assembly Biosciences