Giovanni Mazzocco has 10+ years of experience in academic and commercial bioinformatics projects, including collaborations with scientific institutes (e.g.Università di Padova,Interdisciplinary Centre for Mathematical and Computational Modelling, Centre of New Technologies,Krakow University, Institute of Computer Science at the Polish Academy of Sciences, Jackson Laboratory) medical research institutions, and Pharma/Biotech companies. He conducted research in computational biology including enzyme discovery, molecular modeling, dynamics and interaction assessment of proteins, chromatin modeling, design of statistical learning methods for the prediction of protein interactions of pivotal immunological significance, and design of vaccine constructs to be tested in industrial settings. Giovanni joined Ardigen to pursue the advancement of precision medicine in oncology with the application of AI. Gio is the proponent of the TCRact project, which obtained financing by the Polish Centre for Research and Development and is currently under development in the Ardigen immunology team(ClinicalTrials.gov, NCT04994093). His role is to propose and explore scientific directions in the R&Dteam.
Emerging Therapeutics Showcase:
Ardigen is harnessing advanced AI methods for novel precision medicine. The company’s in-house datasets, together with advanced AI platforms, empower the development of effective therapies.
AI-aided Rational Design of Cancer Cell Therapies
Predicting the interaction of a TCR to target and off-target antigens can support the development of adoptive cell therapies. We will discuss how AI-assisted methods can help by incorporating sequence-level information and general patterns of interactions at the peptide, HLA, and TCR level.
The PMWC 2022 Microbial Profiling Showcase will provide a 15-minute time slot for selected companies in the Microbiome and Pathogen ID fields. The human microbiome is composed of a wide variety of microorganisms that are essential for maintaining human health and preventing disease. Research in this area is accelerating due to the rapid development in genome sequencing technologies. This showcase will present some of the leading companies in microbial profiling and pathogen identification.