Speaker Profile
PMWC PIONEER AWARD
Nobel Laureate & pioneer of vesicle trafficking and cellular protein transport
Ph.D., Nobel Laureate, Professor, UC Berkeley
Biography
Randy W. Schekman is a Nobel laureate and Professor of Molecular and Cell Biology at UC Berkeley. He shared the 2013 Nobel Prize in Physiology or Medicine for discovering the machinery that regulates vesicle transport—how cells organize, package, and deliver cargo such as proteins and hormones. Cellular Transport: He mapped the fundamental genetic and biochemical pathways of yeast cell transport. These discoveries apply directly to human cells and are used widely in the biotech industry (e.g., producing recombinant insulin).
Talk
Trafficking and function of extracellular vesicles
Extracellular vesicles (EVs) are secreted in a process that supports cellular homeostasis. Ordinarily, EVs lack a membrane fusogen and do not efficiently deliver cargo molecules into the cytoplasm of target cells. EVs engineered to contain a viral or endogenous human fusogen are capable of efficiently delivering cargo to target cells.
Session Abstract – PMWC 2027 Silicon Valley
Track Chair:
Catriona Jamieson, UC San Diego
PMWC Award Ceremony
• Emmanuelle Charpentier, Max Planck (J. Craig Venter Visionary Award · Nobel Laureate)
• Jay Bradner, Amgen (Pioneer)
• Adrian Krainer, Cold Spring Harbor Laboratory (Luminary)
• Randy Schekman, UC Berkeley (Nobel Laureate, Pioneer)
Featured Speakers
• Emmanuelle Charpentier, Max Planck
• Randy Schekman, UC Berkeley
• Jay Bradner, Amgen
• Adrian Krainer, Cold Spring Harbor Laboratory
• Alexis C. Komor, UC San Diego
• Nicole Gaudelli, GV
• Rachel Haurwitz, Caribou Bio
• Gene Yeo, UC San Diego
• Timothy Yu, Boston Children's / Harvard
• Shicheng Guo, Arrowhead Pharmaceuticals
• Mark A. Kay, Stanford
• Niren Murthy, UC Berkeley
• Ben Deverman, Broad Institute
• Stanley Crooke, n-Lorem / Ionis
Programming Protein Fate
Molecular glues, degraders, and induced proximity crossing into medicines.
Genome Editing Beyond the First Wave
Base, prime, and CRISPR-enabled editing moving from correction to clinic.
RNA Editing, Splice Modulation & Programmable RNA
RNA editing, ASOs, and splice modulation with chemistry already reaching patients.
In Vivo Delivery & Vector Engineering
AAV, LNP, and next-generation vectors that decide what is treatable.
From N-of-1 to Platform
Evidence, CMC, regulation, and access for individualized genetic medicines.
PMWC Hall of Impact
Previous Speakers Include
Nobel laureates, technology founders, regulators, CEOs and scientific pioneers who have taken the PMWC stage.
