Dr. Peter Smibert leads the Technology Innovation Lab at the New York Genome Center. He performed his PhD research under Prof. Robert Saint at the Australian National University and studied mechanisms of post-transcriptional gene regulation during his post-doc with Dr. Eric Lai at Memorial Sloan-Kettering Cancer Center in New York. At NYGC his team, comprising bio-engineers and molecular biologists, develop novel tools in genomics. Most recently, the lab has focused on single cell genomics, with emphasis on tools obtaining multiple modalities of information from high-throughput single cell assays.
Rapid development of technologies and methods that permit a detailed analysis of the genome and transcriptome of a single cell is offering a window into the extent and nature of genomic and transcriptomic heterogeneity which occurs in both normal development and disease. Single-cell approaches stand poised to revolutionize our capacity to understand the scale of genomic, epigenomic, and transcriptomic diversity that occurs during the lifetime of an individual organism. This session will review the major technological and biological breakthroughs achieved, describe the remaining challenges to overcome, and provide a glimpse into the promise of recent and future developments.