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Mary has been a pioneer in both the science and clinical application of pharmacogenomics. Her research has resulted in seminal laboratory discoveries that unraveled the mechanisms of leukemogenesis and drug resistance; the indentification of novel therapeutic targets, and the integration of biologic, genomic, and pharmacologic discoveries into comprehensive clinical protocols, leading to a markedly improved cure rate for children with acute lymphoblastic leukemia. She has led the implementation of clinical protocols for pharmacogenomics at St. Jude Medical as well as their integration into clinical care, which in the aggregate has saved thousands of children from chemotherapy-related toxicities and death. In recognition for her work she was elected to the Institute of Medicine (now National Academies of Medicine) in 2009 and also received the Pediatric Oncology Award from ASCO. More recently, Mary has been recognized by the American Society for Clinical Pharmacology and Therapeutics, receiving the Rawls Palmer Progress in Medicine Award. Mary led the formation of the Clinical Pharmacogenomics Implementation Consortium (CPIC) that has published pharmacogenetic guidelines for thirty-five drugs, removing a barrier to pharmacogenetic testing in the clinic. These guideline are now being implemented around the globe. Mary received her Bachelor of Science degree from the University of Arizona and her PharmD from University of Utah College of Pharmacy.
Pharmacists have long recognized that using unique patient characteristics to guide pharmacotherapy decision-making can improve drug response and mitigate drug-associated risks. Age, weight, and dietary habits were among the first patient-specific characteristics used to individualize pharmacotherapy. As technologies advanced, analytic tools that measure surrogate markers of liver and renal function, together with drug concentrations in biological fluids, were adopted to optimize therapeutic regimens. Cutting-edge genomic technologies are now being integrated into patient care for the selection of targeted therapies and identification of those at increased risk of poor pharmacotherapy outcomes. Precision Pharmacotherapy is combining genetic, environmental, lifestyle, and other unique patient or disease characteristics to guide drug selection and dosage. This session will introduce the concept and give many examples of how precision pharmacotherapy is used in specialties such as pediatrics, psychology, cardiology and oncology to guide prescribing.