Speaker Profile
PhD, Professor of Obstetrics and Gynecology, OHSU
Biography
Dr. Leslie Myatt applies basic science methodologies to understand the etiology of the major clinical problems in perinatology and develop novel therapeutic approaches. He has published over 300 papers and has served on many review panels for NIH, CIHR and other international grant giving bodies. His current work studies 1. The effects of maternal obesity, gestational diabetes and sexual dimorphism on mitochondrial respiration in the placenta and their relationship to epigenetic regulation of placental function and the Developmental Origins of Health and Disease (DOHaD) and 2. Autocrine-paracrine mechanisms in fetal membranes involved in parturition. Dr. Myatt has served as Editor of the journal Placenta, and as President of the Perinatal Research Society, the International Federation of Placenta Associations and the Society for Gynecologic Investigation. He was presented with the Naftolin Award for Mentorship and the Distinguished Scientist Award by the Society for Reproductive Investigation.
Talk
Fetal Sex Influences Pregnancy and Longterm Outcomes
In utero exposures (stress, toxins, nutritional) epigenetically program the fetus for subsequent development of disease. The male fetus is at greater risk of adverse pregnancy outcomes including stillbirth with sexual dimorphism in placental function. Different therapeutic approaches may be needed for pregnancies with a male vs a female fetus.
Session Abstract – PMWC 2024 Silicon Valley
Track Co-Chairs:
Yoel Sadovsky, UPMC
C. Noel Bairey Merz, Cedars-Sinai Medical Center
The Women's Health Track with a focus on sex differences aims to explore the latest research in this field and highlight the importance of sex-specific analysis in healthcare. The full-day track includes sessions on enhancing women's health research, general sex differences in large studies, pregnancy (Feto-placental) and sex differences, the biology underlying sex differences, and systems and sex differences. The confirmed speakers are leading experts in their respective fields, including cardiovascular medicine, immunology and virology, metabolic disease, Alzheimer's disease, autism, diabetes, exercise, and hypertension. Through this track, attendees will gain valuable insights into the latest research on sex differences in healthcare and the importance of personalized medicine for women.
- PMWC 2024 Award Ceremony
Pioneer Honoree: David Page, MIT
Luminary Honoree: Janine Austin Clayton, NIH
- Keynote: Enhancing Women's Health Research
- Janine Austin Clayton, NIH
- Keynote: Inclusive Research for Better Health: The FDA's Perspective on Sex Differences in Clinical Trials
- Kaveeta Vasisht, FDA
- Keynote: The Chromosomal Basis of Sex Differences in Health and Disease
- David Page, Whitehead Institute
- General Sex Differences in Large Studies
Chair: Karen Reue, UCLA (Sex Differences in Metabolic Disease)
- Franck Mauvis-Jarvis, Tulane University (Sex Differences in Insulin Resistance) - Feto-placental Sex Differences
Chair: Yoel Sadovsky, University of Pittsburgh
- Nima Aghaeepour, Stanford (AI Taxonomy for Reproductive Health)
- Leslie Myatt, OHSU Oregon (Fetal Sex and Pregnancy Outcomes)
- Systems and Sex Differences
Chair: Marcia Stefanick, Stanford (Sex differences in Cancer)
- Judy Regensteiner, University of Colorado (Sex and Gender: Focus on Diabetes)
- Monica Gandhi, UCSF (Sex Differences in HIV) - Cardiovascular Sex Differences
- Martha Gulati, Cedars Sinai - Sex Differences in Alzheimer's Disease
Chair: Marina Sirota, UCSF (Sex Differences in Alzheimer's Disease Using Clinical, Molecular, and Computational Approaches)
- Sarah Banks, UCSD (Sex Differences in Tau Pathology and AD Modifiable Risk)
- Roberta Brinton, University of Arizona (Illuminating Path to Alzheimer's Cure) - Sex Differences and Cognitive-behavioral Function
Chair: Debra Kaysen, Stanford (Gender Effects on Trauma Exposure, PTSD, and Treatment)
