Biography
Lawrence (Lance) Prince, MD, PhD, is the Division Chief for Neonatal and Developmental Medicine at Stanford. Dr. Prince’s research interests include the molecular and cellular mechanisms controlling lung development and the maturation of the fetal and neonatal immune systems. He has a particular clinical interest in managing and treating neonatal lung diseases, especially bronchopulmonary dysplasia (BPD) in babies born extremely preterm. Dr. Prince’s research team focuses primarily on the development of innate immunity during fetal life as it impacts health and disease in preterm infants. The laboratory is investigating how microbes including Group B streptococcus exploit the unique features of neonatal macrophages to avoid immune detection and cause disease, as well as leading a number of clinical and translational investigations.

Talk
Neonatal Molecular Precision Medicine and Disease Resilience
While the complications of extreme prematurity can be devastating, many patient have excellent outcomes. In studying the molecular basis for the chronic lung disease bronchopulmonary dysplasia, we identified programs of gene expression correlating with disease protection or resilience. We hope that future genomic studies will help identify therapies that will help achieve normal human development.