Speaker Profile
PhD, Professor, UCLA
Biography
The Reue laboratory seeks to identify genes, pathways, and the role of sex in the development of traits underlying the Metabolic Syndrome, including obesity, dyslipidemia, and insulin resistance. Using genetic manipulation in mouse models, this research has revealed independent roles for gonadal hormones and sex chromosomes in dietary lipid absorption, regulation of circulating lipid levels, development of adipose tissue, mitochondrial function, and statin related diabetes.
Talk
Sex Differences In Metabolic Disease
The prevalence and presentation of cardiometabolic diseases is sexbiased. Studies that dissociate chromosomal sex (XX vs. XY) and gonadal sex (ovaries vs. testes) have uncovered mechanisms for sexbiased gene regulation in conditions such as obesity, atherosclerosis, autoimmune disease and Alzheimers disease. This information may inform sexspecific disease prevention and treatment.
Session Abstract – PMWC 2024 Silicon Valley
Track Co-Chairs:
Yoel Sadovsky, UPMC
C. Noel Bairey Merz, Cedars-Sinai Medical Center
The Women's Health Track with a focus on sex differences aims to explore the latest research in this field and highlight the importance of sex-specific analysis in healthcare. The full-day track includes sessions on enhancing women's health research, general sex differences in large studies, pregnancy (Feto-placental) and sex differences, the biology underlying sex differences, and systems and sex differences. The confirmed speakers are leading experts in their respective fields, including cardiovascular medicine, immunology and virology, metabolic disease, Alzheimer's disease, autism, diabetes, exercise, and hypertension. Through this track, attendees will gain valuable insights into the latest research on sex differences in healthcare and the importance of personalized medicine for women.
- PMWC 2024 Award Ceremony
Pioneer Honoree: David Page, MIT
Luminary Honoree: Janine Austin Clayton, NIH
- Keynote: Enhancing Women's Health Research
- Janine Austin Clayton, NIH
- Keynote: Inclusive Research for Better Health: The FDA's Perspective on Sex Differences in Clinical Trials
- Kaveeta Vasisht, FDA
- Keynote: The Chromosomal Basis of Sex Differences in Health and Disease
- David Page, Whitehead Institute
- General Sex Differences in Large Studies
Chair: Karen Reue, UCLA (Sex Differences in Metabolic Disease)
- Franck Mauvis-Jarvis, Tulane University (Sex Differences in Insulin Resistance) - Feto-placental Sex Differences
Chair: Yoel Sadovsky, University of Pittsburgh
- Nima Aghaeepour, Stanford (AI Taxonomy for Reproductive Health)
- Leslie Myatt, OHSU Oregon (Fetal Sex and Pregnancy Outcomes)
- Systems and Sex Differences
Chair: Marcia Stefanick, Stanford (Sex differences in Cancer)
- Judy Regensteiner, University of Colorado (Sex and Gender: Focus on Diabetes)
- Monica Gandhi, UCSF (Sex Differences in HIV) - Cardiovascular Sex Differences
- Martha Gulati, Cedars Sinai - Sex Differences in Alzheimer's Disease
Chair: Marina Sirota, UCSF (Sex Differences in Alzheimer's Disease Using Clinical, Molecular, and Computational Approaches)
- Sarah Banks, UCSD (Sex Differences in Tau Pathology and AD Modifiable Risk)
- Roberta Brinton, University of Arizona (Illuminating Path to Alzheimer's Cure) - Sex Differences and Cognitive-behavioral Function
Chair: Debra Kaysen, Stanford (Gender Effects on Trauma Exposure, PTSD, and Treatment)
