Speaker Profile

M.D., Ph.D., CEO, Twinstrand Biosciences

Dr. Jesse Salk is a medical oncologist and a Co-Founder of TwinStrand Biosciences. His research interests lie in studying somatic evolution and the genomic processes that occur on the continuum between “normal”, preneoplastic and cancer, and applying this to knowledge to clinical medicine. He developed the ultra-high accuracy Duplex Sequencing technology with colleagues at the University of Washington, where he completed his medical and graduate degrees as well as clinical training. Since 2017, Dr. Salk has led TwinStrand, applying Duplex Sequencing to new areas of high sensitivity early and residual cancer detection, evolution of drug resistance and genetic toxicology, among other fields. He holds a clinical faculty appointment at the University of Washington and continues to care for cancer patients part time at the VA Puget Sound in Seattle.

Clinical Dx showcase:
Twinstrand Biosciences

TwinStrand develops ultrasensitive Duplex Sequencing-based assays for research and clinical applications in cancer, cancer therapeutics and other areas of basic science and clinical medicine.

Duplex Sequencing for Gene Editing and Cell Therapy Applications
Duplex Sequencing enables an unprecedented level of NGS accuracy, with error rates below one-in-ten-million. The technology is ideally suited to detection of exceptionally low frequency DNA variants. Here we present Duplex Sequencing for cutting-edge gene editing and cellular therapy applications.

 Session Abstract – PMWC 2022 Silicon Valley

Track Chair:
Vanessa Soros, Graphite Bio


  • Gene & Cell Therapies Overview
    - Janice Chen, Mammoth
  • Advances in Gene & Cell Therapies
    Session Chair: Vanessa Soros, Graphite Bio
    - Mark McKee, Intellia Tx
    - Amy Simon, Beam Therapeutics
    - Eric Ostertag, Poseida Therapuetics
  • Translating CGT to the Clinic (PANEL)
    Session Chair: Nicole K. Paulk, UCSF
    - Matthew Porteus, Stanford
    - Eric Crombez, Ultragenyx Gene Therapy
    - Peter Francis, 4D Molecular Therapeutics
    - Erandi De Silva, Forge Biologics
    - Patrice Hugo, Q2 Solutions
  • PMWC Showcase
    - Yuri Fesko, Labcorp
    - Yan Zhang, Mission Bio
    - Anil Narasimha, Mekonos Inc.
    - Emily Anderson, Horizon, a PerkinElmer Company
    - Peter Marinkovich, Stanford
    - Jesse Salk, Twinstrand
    - William Shrader, AcureX Therapeutics
  • Past, Present and Future of CRISPR Where will CRISPR Take Us and How is the Technology Evolving to Realize its Full Potential (PANEL)
    Session Chair: Janice Chen, Mammoth
    - Kiana Aran, Cardea Bio
    - Mark McKee, Intellia Tx
    - Josh Lehrer, Graphite Bio