Speaker Profile
Ph.D., Principal Scientist, Horizon, PerkinElmer
Biography
Emily has managed projects involving the development and application of gene engineering and gene modulation technologies including Dharmacon™ ON-TARGETplus™ siRNA and Accell™ siRNA, as well as the introduction of Dharmacon™ Edit-R™, the first rationally-designed, genomewide library of synthetic CRISPRs for gene disruption. She received a Ph.D. in Biochemistry from the University of Colorado at Boulder on the structure and function of protein:single-stranded DNA interactions at telomeres. She has worked extensively on the mechanism, function, specificity, and delivery of RNAi as well as its applications. She is an inventor on many issued patents and has authored peer-reviewed publications in the fields of both RNAi and CRISPR.
Talk
Pin-point™ – Modular Base Editing for Clinical Applications
Pin-point™ uses aptameric guide RNA for deaminase recruitment. We demonstrate in CAR-T cells multitargeting of several therapeutically relevant loci, retaining proliferative and cytotoxic ability, including advantages over Cas9. Aptameric recruitment enables simultaneous knock-in and knockout and allows targeting polygenic disorders.
Session Abstract – PMWC 2022 Silicon Valley
Track Chair:
Vanessa Soros, Graphite Bio
Sessions:
- Gene & Cell Therapies Overview
- Janice Chen, Mammoth
- Cutting Edge Technologies for Gene Engineering and Cell Therapy (PANEL)
Session Chair: Vanessa Soros, Graphite Bio
- Mark McKee, Intellia Tx
- Amy Simon, Beam Therapeutics
- Eric Ostertag, Poseida Therapuetics
- Translating CGT to the Clinic (PANEL)
Session Chair: Nicole K. Paulk, UCSF
- Matthew Porteus, Stanford
- Peter Francis, 4D Molecular Therapeutics
- Erandi De Silva, Forge Biologics
- Patrice Hugo, Q2 Solutions
- Susanne Fors, Ultragenyx - PMWC Showcase
- Yuri Fesko, Labcorp
- Yan Zhang, Mission Bio
- Anil Narasimha, Mekonos Inc.
- Emily Anderson, Horizon, a PerkinElmer Company
- Jesse Salk, Twinstrand
- William Shrader, AcureX Therapeutics - Emerging Gene Therapies for Epidermolysis Bullosa
- Peter Marinkovich, Stanford - Past, Present and Future of CRISPR Where will CRISPR Take Us and How is the Technology Evolving to Realize its Full Potential (PANEL)
Session Chair: Janice Chen, Mammoth
- Kiana Aran, Cardea Bio
- Mark McKee, Intellia Tx
- Josh Lehrer, Graphite Bio
