Dr. Swaney's lab is focused on using proteomics to enable biological discoveries. During her PhD training at the University of Wisconsin she developed novel approaches to study phosphorylation signaling, and leveraged these approaches during her postdoctoral training at the University of Washington to enable high-throughput characterization of crosstalk between phosphorylation and ubiquitin signaling. Recently Dr. Swaney's lab has been focused on the discovery of protein-protein interactions and phosphorylation signaling that regulates SARS-CoV-2 infection.
Discovery of SARS-CoV-2 Host-protein Targets for Antiviral Drug Repurposing
Viruses hijack host proteins to promote viral replication and evade immune response. Here we have used proteomics approaches to identify hijacked host proteins, revealing numerous drugs in clinical trial or with FDA-approval that both target these hijacked proteins and inhibit SARS-CoV-2 infection in vitro.