Speaker Profile

M.D., Professor of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA

Biography
Dr. Karumanchi’s laboratory is focused on discovering pathogenic pathways and bringing therapies to patients in the areas of hypertensive disorders of pregnancy and chronic kidney diseases. Dr. Karumanchi’s research activities are vertically integrated, ranging from molecular and cell biological studies to animal models to first-in-class human clinical trials. Dr. Karumanchi has published over 300 papers (with several publications in NEJM, Circulation, Nature, Nature Medicine, JCI) and 25 book chapters. He has received prestigious awards from several societies including recognitions from American Heart Association (AHA) – Established Investigator Award (2008), the International Society for the Study of Hypertension in Pregnancy – Chesley Award (2010) – and Outstanding Investigator Award from the American Federation for Medical Research (2010). He was also elected as a member of the American Society for Clinical Investigation in 2007 and Association of American Physicians in 2015. His work in Preeclampsia has been highlighted in The New York Times, New Yorker, Boston Globe and LA Times. Dr. Karumanchi completed his medical degree from Kilpauk Medical College, India in 1992. He then completed his residency in Internal Medicine at the Henry Ford Hospital, Detroit (1996) and his post-doctoral training in Molecular Biology at the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston (2000).

Talk
Targeted Therapies for Preeclampsia
Circulating anti-angiogenic proteins of placental origin are responsible for the maternal signs and symptoms of preeclampsia. We will present data for short interfering RNAs that selectively silence placental expression of anti-angiogenic proteins responsible for the human disease. Our results demonstrate a feasible path toward a new treatment paradigm for patients with preeclampsia.


 Session Abstract – PMWC 2022 Silicon Valley


Track Co-Chairs:
Aleksandar Rajkovic, UCSF
Kathryn G. Schubert, Society for Women's Health Research

Researchers have long been recognizing the uniqueness of women’s health and its substantial effect on clinical practice, acknowledging the increasing appreciation of the importance of multidisciplinary approaches to health and disease. In every organ system, there are diseases that are unique to women, more common in women than in men, or characterized by differences in disease course in women compared to men. This Track will focus on the following topics related to Women’s Health:

  • Intro to Women's Health
    - Aleksandar Rajkovic, UCSF
  • US Regulatory/Personalized Medicine and Women's Health
    Session Chair: Kathryn G. Schubert, SWHR
    - Kaveeta Vasisht, FDA
  • Reproductive Health
    - Hakan Cakmak, UCSF
    - Linda G. Griffith, MIT
    - Laura Jelliffe-Pawlowski, UCSF
  • Pregnancy
    Session Chair: Yoel Sadovsky, UPMC
    - Virginia D. Winn, Stanford
    - Ananth Karumanchi, Cedars-Sinai Medical Center
    - Liang Liang, Stanford
    - Mira Moufarrej, Stanford University
  • Biological Sex Differences in Disease + Inclusion of Women in Clinical Research/Innovation
    - Rhonda Voskuhl, UCLA
  • Cardiovascular Health
    - Nisha Parikh, UCSF
    - Michael Honigberg, Massachusetts General Hospital
    - Jennifer Ann Tremmel, Stanford
  • Bone Health/Osteoporosis & Menopause
    Session Chair: Risa Kagan, Sutter Health
    - Danit Ariel, Stanford
    - Massimiliano (Max) de Zambotti, SRI International
  • Showcase
    - Nathan D. Price, Onegevity
    - Maneesh Jain, MirVie
    - Kevin P. Rosenblatt, NX Prenatal
    - Ripudaman Singh, ARCEDI Biotech
    - Michelle Perugini, Presagen
    - Claire Tomkins, Future Family