Session Abstract – PMWC 2020 Silicon Valley


The Molecular Tumor Board (MTB) was mostly established to facilitate the incorporation of molecular diagnostics into the consideration of appropriate therapies for patients with late stage cancer. Initially, much of the deliberation was focused on understanding the results of such testing, as reporting of results was limited in scope and frequently understandable only to cutting edge experts in the field. Improved, but still not perfect, reporting now exists, so discussion has shifted to prognostic and therapeutic considerations. That said, the collective experience with rare mutations and off label therapies is still such that collective wisdom is necessary. This brings up the issue of how MTBs collect, share, and preserve data within a specific MTB, and perhaps more importantly, how it might be shared amongst MTBs and beyond. While initial activity related to MTBs resided almost exclusively in large academic, and select community, medical centers, there is now significant effort in the commercial setting as well, with a number of intriguing efforts presently underway. Important and evolving issues, such as defining which patients are most likely to benefit from the efforts of a MTB, Virtual MTBs, and the generation of Real World Evidence, will be discussed.

 Session Chair Profile

M.D., Deputy Director for Molecular Pathology and Genomics, Swedish Cancer Institute

Biography
Dr. Anna Berry is the Deputy Director for Molecular Pathology and Genomics at the Swedish Cancer Institute, where she also serves as the Scientific Director of the Personalized Medicine Program. She is a graduate of the University of Nebraska Medical Center, and completed her post-graduate training at SUNY Upstate Medical University, the Medical College of Virginia, and the National Cancer Institute. Dr. Berry is Board Certified in Molecular Genetic Pathology, Cytopathology, Anatomic Pathology and Clinical Pathology, and served previously as the Director of Molecular Pathology and the Director of the Molecular Genetic Pathology fellowship training program at UCSF. Her clinical focus is making genomic technologies accessible to patients, and integrating genomic data into patient care. She serves on several national committees, including the Personalized Healthcare Committee of the College of American Pathologists, and participates in several national genomics task forces.


 Speaker Profile

M.D.,Ph.D., Co-Director Oncology Precision Medicine Program, Aurora Cancer Care, Advocate Aurora Health

Biography
Dr. Thompson is on the ECOG-ACRIN Myeloma and Lymphoma Core committees. He is currently on the NCI Lymphoma Steering Committee. At ASCO he was a member of the Cancer Research Committee. Dr. Thompson was Chair (2016-2017) of the ASCO Research Community Forum. He was Chair (2016-2017) of the ASCO Education Committee. Medical Director of the Early Phase Cancer Research Program. Co-PI of the Aurora NCI Community Oncology Research Program (NCORP) and is co-Director of Aurora’s Oncology Precision Medicine program. He received his BS in Molecular Biology - Honors from the University of Wisconsin - Madison, his MD at Mayo Medical School, and PhD in Molecular Pharmacology and Experimental Therapeutics from the Mayo Graduate School in the pharmacogenetics laboratory of Richard Weinshilboum, MD. He completed his Internal Medicine Residency at the Mayo Clinic College of Medicine. His Hematology/Oncology Fellowship was at the MD Anderson Cancer Center.


 Speaker Profile

M.D., Ph.D., F.A.C.P., Director, Comprehensive Cancer Center of Wake Forest University; Chair, Department of Cancer Biology Wake Forest Baptist Health Sciences

Biography
As Director of the Comprehensive Cancer Center of Wake Forest University, Dr. Pasche holds the Charles L Spurr Endowed Chair in Cancer Research at Wake Forest Baptist Health Sciences and serves as the Chair of the Department of Cancer Biology. He received a M.D. degree from the University of Lausanne (Switzerland), M.D. and Ph.D. degrees from the Karolinska Institute (Stockholm, Sweden), postdoctoral research training at the Brigham and Women’s Hospital, Harvard Medical School, Internal Medicine training at the New York Hospital, Cornell Medical Center, and Hematology/Oncology training at Memorial Sloan-Kettering Cancer Center. He was the founder and Director of Cancer Genetics Program (Northwestern School of Medicine). He was the Chief of the Division of Hematology/Oncology at the University of Alabama at Birmingham and served as Deputy Director at the University of Alabama at Birmingham Comprehensive Cancer Center. Dr. Pasche’s research has focused on cancer susceptibility and new therapies for cancer. He has developed a new medical device for the treatment of hepatocellular carcinoma, which received European regulatory approval in 2018. Dr. Pasche has published more than 120 peer-reviewed articles, book chapters and editorials, many of which appeared in high impact journals.


 Speaker Profile

M.D., Ph.D., Associate Director for Translational Research, The Rutgers Cancer Institute of New Jersey

Biography
Dr. Ganesan is Associate Director for Translational Research and Chief of the Section of Molecular Oncology at the Rutgers Cancer Institute of New Jersey. His research focus on the role of genomic instability and epigenetic instability in cancer, and the use of cancer genomics for cancer classification and treatment. His laboratory contributed to better understanding of the roles of BRCA1 and 53BP1 in DNA repair choice . His recent work has focused on novel genomic markers of response and resistance to chemotherapy, targeted therapy and immunotherapy. In the clinic, Dr. Ganesan takes care of patients with breast cancer and rare cancer , is the co-Leader of the Clinical Investigations and Precision Therapeutics program and runs the molecular tumor board at RCINJ. He has authored or co-authored over 100 peer-reviewed publications. Dr. Ganesan received his undergraduate education at Princeton, his M.D. and Ph.D. at Yale, and his clinical training at the Brigham and Women’s Hospital and Dana Farber Cancer Institute.


 Speaker Profile

M.D., Professor of Medicine and Radiology, Stanford University; Director, Phase I Clinical Research Program-Medical Oncology; Director, Translational Oncology Program At Stanford

Biography
Dr. Kummar is Professor of Medicine and Director of the Phase I Clinical Research and Translational Oncology Programs at Stanford University. Prior to joining Stanford in 2015, Dr. Kummar served as the Head of Early Clinical Trials Development in the Office of the Director, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland. Her research interests focus on developing novel therapies for cancer, conducting pharmacokinetic and pharmacodynamic driven first-in-human trials. The clinical studies integrate genomics, imaging, and laboratory correlates into early phase trials. She serves on multiple national and international scientific committees and has published >125 papers in peer review journals.


 Speaker Profile

M.D., Medical Director, The Jackson Laboratory Cancer Center

Biography
Jens Rueter is the Medical Director for the Maine Cancer Genomics Initiative at The Jackson Laboratory (JAX) and the Associate Director for Regional Translational Partnerships at the JAX Cancer Center. He joined JAX for these positions in August 2016. He has overseen the implementation of a unique precision medicine program that has enrolled physicians and patients statewide across multiple healthcare systems and established statewide genomic tumor boards. The MCGI team is working with several national precision oncology leaders with the goal of individualizing cancer treatments for individual patients and improving their outcomes. Previously, Dr. Rueter was a hematologist/oncologist at EMMC Cancer Care and the Medical Director for EMMC Biobank and translational research in Brewer, Maine. After graduating from medical school in Berlin, Germany, Rueter completed his residency in internal medicine at Tulane University and fellowship training in hematology/oncology at the University of Pennsylvania.


 Speaker Profile

PharmD, Assistant Member, Personalized Medicine Specialist, Moffitt Cancer Center

Biography
As an attending on Moffitt’s Personalized Medicine Clinical Service Dr. Knepper’s clinical focus is on the utilization of genomic technologies to optimize treatment for patients with solid and hematologic malignancies. Dr. Knepper’s research focus is translating cancer genomics towards advancing the understanding of cancer treatment and biology, with a particular interest in rare malignancies. Prior to his current role Dr. Knepper was the inaugural Personalized Cancer Medicine Fellow at Moffitt Cancer Center and graduated from the University of North Carolina – Eshelman School of Pharmacy as a Joe Hollingsworth Scholar. At Moffitt, he has been integral in the creation and development of the molecular tumor board. He has also gained regulatory experience as an ORISE fellow at the US FDA, embedded with the Genomics and Targeted Therapy group and interacting with the Office of Hematology and Oncology Products. He has published in the Journal of Clinical Oncology, Blood, and Nature.


 Speaker Profile

Ph.D., Professor and Chair, Beckman Research Institute of the City of Hope, Founding Director, Biotech Innovations, City of Hope Comprehensive Cancer Center

Biography
Dr. Goel has been recognized as an American Gastrointestinal Association Fellow (AGAF) for his research on colorectal cancer. In fact, Dr. Goel has spent more than 20 years researching cancer and has been the lead author or contributor to over 300 scientific articles published in peer reviewed international journals and several book chapters. He is currently researching the prevention of gastrointestinal cancers using integrative and alternative approaches, including botanical products. Three of the primary botanicals he is investigating are curcumin (from turmeric), boswellia, and French grape seed.


 Speaker Profile

M.D., Pediatric Neuro-Oncologist, UCSF

Biography
Dr. Kline is a pediatric neuro-oncologist who specializes in caring for children, adolescents, and young adults with brain and spinal cord tumors of all types. In addition to clinical care, Dr. Kline has extensive research experience, and is involved in numerous studies. She has a Master’s of Advanced Studies in Clinical Research and focuses on early phase clinical trials and developmental therapeutics for pediatric brain tumor patients. Dr. Kline’s other research interests include predictors of neurocognitive outcomes in pediatric brain tumor survivors and personalized and immunotherapy-based approaches for the treatment of brain tumors.


 Speaker Profile

M.D., Director, Molecular Pathology and Pathology Informatics, Providence St. Joseph Health

Biography
Dr. Bifulco is a Surgical Pathologist with additional fellowship subspecialty training, expertise, and board certification in Molecular Genetic Pathology and Hematopathology. Dr. Bifulco serves on the Global Colon Cancer Immunoscore Task Force led by the Society for Immunotherapy of Cancer (SITC), and is Chair of the SITC Pathology Task convened to establish multiplexed immunohistochemistry/immunofluorescence (mIHC/IF) standards. Prior to joining Providence, Dr. Bifulco served on the Pathology faculty at the National Cancer Center in Milan/Italy, at the University of Florida and at Yale University, and completed fellowships in Hematopathology at Yale and in Oncologic Surgical Pathology and Molecular Genetic Pathology at Memorial Sloan Kettering Cancer Center. Dr. Bifulco currently serves as the Director of Molecular Pathology and Pathology Informatics at Providence St. Joseph Health, and as the Director of Translational Molecular Pathology and Molecular Genomics at the Earle A. Chiles Research Institute in Portland, Oregon, a division of the Providence Cancer Institute. He oversees the PSJH Molecular Genomics Laboratory, one of the largest clinical genomics labs in the Pacific Northwest, which provides state-of-the-art genomic sequencing to cancer patients across the seven state PSJH system. His current translational research is focused on supporting the characterization of the tumor immune microenvironment through immunohistochemical and image analysis techniques, and on the integration of genomics with immunotherapies.