Session Abstract – PMWC 2024 Silicon Valley

Track 4 - January 24 9.00 A.M.-4.45 P.M.


Track Chair: Keith Yamamoto, UCSF

  • PMWC 2024 Award Ceremony:
    Luminary Honoree: Geoff Ginsburg, NIH (All of Us)
  • Fireside Chat: Geoff Ginsburg, NIH and Keith Yamamoto, UCSF
  • New Federal Programs Driving Transformative Health Breakthroughs (PANEL)
    Chair: Keith Yamamoto, UCSF
    - Arunan Skandarajah, ARPA-H
    - Susan Marqusee, NSF
    - Sheng Lin-Gibson, NIST
  • AI-driven Advances in Precision Medicine (PANEL)
    Chair: Sharat Israni, Bakar Institute, UCSF
    - Suzanne Tamang, Stanford
    - Colleen Clancy, UC Davis
    - Nevan Krogan, UCSF
    - Lauren Erdman, University of Toronto
  • Precision Medicine in New Research Frameworks (PANEL)
    Chair: Regis B. Kelly, UCSF
    - Joe DeRisi, UCSF
    - Luke Gilbert, UCSF
    - Prachee Avasthi, Arcadia Science
  • Living Therapeutics for Precision Medicine
    Chair: Michelle Hermiston, UCSF
    - Peter Marks, FDA
    - Wendell Lim, UCSF
    - Liora Schultz, Stanford
  • AI and Precision Medicine: Navigating Equity and Social Justice Challenges (PANEL)
    Chair: Hank Greely, Stanford
    - Ziad Obermeyer, UC Berkeley
    - Sara L. Ackerman, UCSF

 Speaker Profile

PhD, Vice Chancellor for Science Policy and Strategy, UCSF

Biography
Dr. Yamamoto is a leader in science and public policy. He has made an indelible impact by simultaneously advocating for Precision Medicine across the .edu, .gov, .com and .org sectors. As Chair of the National Academies Board on Life Sciences, he appointed and served on the study committee that produced Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease, the report that enunciated the precision medicine concept. He helped to stimulate President Obama's interest, which led to the Precision Medicine Initiative, as well as Gov. Jerry Brown's launch of the California Initiative to Advance Precision Medicine. He also promoted a precision medicine approach to Vice President Biden's Cancer Moonshot, provoked broader participation by the corporate and nonprofit sectors, and directs UCSF Precision Medicine, an institutionwide imperative. In addition, Dr. Yamamoto has led or served on numerous federal or national committees focused on public and science policy, public understanding and support of biological research, research funding and peer review, and science education and the biomedical workforce; he chairs the Coalition for the Life Sciences, and sits on the National Academy of Medicine Council and Executive Committee, and the National Academy of Sciences Division of Earth and Life Studies Advisory Committee. He is a member of the Advisory Board for Lawrence Berkeley National Laboratory and the Board of Directors and Executive Committee of Research!America. At UCSF, Dr. Yamamoto is vice chancellor for science policy and strategy and professor of cellular and molecular pharmacology. He is a leading researcher, investigating transcriptional regulation by nuclear receptors, which mediate the actions of essential hormones and cellular signals; he uses mechanistic and systems approaches to pursue these problems in pure molecules, cells and whole organisms. He is an elected member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Academy of Microbiology, and a fellow of the American Association for the Advancement of Science.


 Speaker Profile

PMWC LUMINARY AWARD
Pioneered innovative diagnostics and collaborative genotyping and phenotyping through national initiatives

MD, PhD, Chief Medical and Scientific Officer, All of Us/NIH

Biography
Geoffrey S. Ginsburg is a renowned physician-scientist and expert in personalized medicine and genomic medicine. He has made significant contributions to the field through his research, leadership, and collaborations. Throughout his career, Ginsburg has demonstrated a strong commitment to interdisciplinary science and innovation, with work spanning oncology, infectious diseases, cardiovascular disease, and metabolic disorders. He has held leadership roles in the U.S. and internationally, serving as co-chair of the National Academies Roundtable on Genomic and Precision Health, a founding co-chair of the International HundredK+ Cohorts Consortium, and founder and president of the Global Genomic Medicine Collaborative (G2MC), a notforprofit organization aimed at creating international partnerships to advance the implementation of precision medicine.


 Speaker Profile

PhD, PHARMD, CTO & NIH Data Scholar 2022-23, UCSF

Biography
Sharat Israni previously was Executive Director, Data Science, at Stanford Medicine. A long serving Technology executive, Sharat’s teams pioneered the use of Big Data. He served as VP of Data at Yahoo! (19992008) and Intuit (201013), which pioneered Big Data Science to reinvent their products. He led Digital Media systems for broadcast interactive TV at Silicon Graphics; and Data teams at IBM and HP. Sharat has been PI for NSF, NIH and RCUK workshops on Data Science topics in Biomedicine, and is a peer reviewer of some scientific journals.


 Speaker Profile

PhD, Assistant Professor in the Department of Medicine, Stanford

Biography
Dr. Suzanne Tamang an Assistant Professor, Dept of Medicine and a Faculty Fellow at the Stanford Center for Population Health Sciences. She is also a Senior Computer Scientist at the Dept of Veterans Affairs. Dr. Tamang uses her training in biology, computer science, health services research and biomedical informatics to work with interdisciplinary teams of experts on population health problems. Integral to her research, is the analysis of large and complex health datasets, using techniques from natural language processing, machine learning and deep learning. Her expertise spans US and Danish population based registries, Electronic Medical Records, healthcare claims and other types of observational health data sources; also, designing, populating and applying knowledge bases for automated reasoning. Dr. Tamang has developed opensource tools for text mining and licensed machine learning prediction models to Silicon Valley health analytics startups. She is the faculty mentor for the Stanford community working group Stats for Social Good.


 Speaker Profile

PhD, Professor, UC Davis

Biography
Colleen E. Clancy has made significant contributions to the UC Davis School of Medicine, where she has played pivotal roles in academic personnel actions, including recruitment, appointment, merit reviews, faculty development, and more. She has chaired the UC Systemwide Committee on Affirmative Action and Diversity and has been involved in various committees and task forces at UC Davis. Recognized for her leadership, Clancy is an alumna of the National Executive Leadership in Academic Medicine (ELAM) program and has received numerous awards, including the 2014 Dean's Excellence in Mentoring Award and the 2020 UC Davis School of Medicine Research Award. A prolific author, Clancy has over 100 published works and serves in editorial and advisory capacities for several journals and organizations. Her research, supported by multiple NIH programs, focuses on computational modeling and simulation of physiological systems.


 Speaker Profile

PhD, Investigator, Gladstone Institute; Professor, Cellular & Molecular Pharmacology and Director Quantitative Biosciences Institute, UCSF

Biography
Nevan Krogan is a distinguished molecular biologist with a focus on understanding the mechanisms of complex diseases. His work has been instrumental in mapping intricate networks of molecular interactions, providing invaluable insights into various diseases and psychiatric disorders. Dr. Krogan's commitment to global scientific collaboration was evident during the COVID19 pandemic, where he played a pivotal role in the formation of an international alliance of scientists dedicated to understanding the biology of SARSCoV2 and identifying potential therapeutic targets. In recognition of his outstanding contributions to science, Dr. Krogan was awarded France's highest honor, the Legion of Honor, in 2022, and the Research!America Discovery Innovation Health Prize in 2023. These prestigious accolades celebrate his exceptional efforts in fostering FrancoAmerican scientific collaborations, particularly during the COVID19 pandemic, where his leadership facilitated rapid, coordinated responses to the global health crisis.


 Speaker Profile

PhD, Assistant Professor, Cincinnati Children's

Biography
Lauren Erdman's research is primarily focused on developing and applying machine learning methods for translational discovery to improve the management and outcomes of complex diseases across many clinical specialties, primarily in pediatrics.


 Speaker Profile

PhD, Vice Chancellor for Science Policy and Strategy, UCSF

Biography
Dr. Yamamoto is a leader in science and public policy. He has made an indelible impact by simultaneously advocating for Precision Medicine across the .edu, .gov, .com and .org sectors. As Chair of the National Academies Board on Life Sciences, he appointed and served on the study committee that produced Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease, the report that enunciated the precision medicine concept. He helped to stimulate President Obama's interest, which led to the Precision Medicine Initiative, as well as Gov. Jerry Brown's launch of the California Initiative to Advance Precision Medicine. He also promoted a precision medicine approach to Vice President Biden's Cancer Moonshot, provoked broader participation by the corporate and nonprofit sectors, and directs UCSF Precision Medicine, an institutionwide imperative. In addition, Dr. Yamamoto has led or served on numerous federal or national committees focused on public and science policy, public understanding and support of biological research, research funding and peer review, and science education and the biomedical workforce; he chairs the Coalition for the Life Sciences, and sits on the National Academy of Medicine Council and Executive Committee, and the National Academy of Sciences Division of Earth and Life Studies Advisory Committee. He is a member of the Advisory Board for Lawrence Berkeley National Laboratory and the Board of Directors and Executive Committee of Research!America. At UCSF, Dr. Yamamoto is vice chancellor for science policy and strategy and professor of cellular and molecular pharmacology. He is a leading researcher, investigating transcriptional regulation by nuclear receptors, which mediate the actions of essential hormones and cellular signals; he uses mechanistic and systems approaches to pursue these problems in pure molecules, cells and whole organisms. He is an elected member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Academy of Microbiology, and a fellow of the American Association for the Advancement of Science.


 Speaker Profile

MD, PhD, Chief Medical and Scientific Officer, All of Us / NIH

Biography
Geoffrey S. Ginsburg is a renowned physician-scientist and expert in personalized medicine and genomic medicine. He has made significant contributions to the field through his research, leadership, and collaborations. Throughout his career, Ginsburg has demonstrated a strong commitment to interdisciplinary science and innovation, with work spanning oncology, infectious diseases, cardiovascular disease, and metabolic disorders. He has held leadership roles in the U.S. and internationally, serving as co-chair of the National Academies Roundtable on Genomic and Precision Health, a founding co-chair of the International HundredK+ Cohorts Consortium, and founder and president of the Global Genomic Medicine Collaborative (G2MC), a notforprofit organization aimed at creating international partnerships to advance the implementation of precision medicine.


 Speaker Profile

MD, PhD, Director, CBER, FDA

Biography
Peter Marks received his graduate degree in cell and molecular biology and his medical degree at New York University and completed Internal Medicine residency and HematologyMedical Oncology training at Brigham and Women's Hospital in Boston. He has worked in academic settings teaching and caring for patients and in industry on drug development. He joined the FDA in 2012 as Deputy Center Director for CBER and became Center Director in 2016.


 Speaker Profile

JD, Professor of Law; Professor by Courtesy of Genetics, Stanford

Biography
Henry T. (Hank) Greely specializes in ethical, legal, and social issues arising from the biosciences. He is a founder and a past President of the International Neuroethics Society; chairs the California Advisory Committee on Human Stem Cell Research; chairs the Ethical, Legal, and Social Issues Committee of the Earth BioGenome Project; and served from 2016 to 2022 on the NIH BRAIN Initiatives MultiCouncil Working Group while cochairing its Neuroethics Work Group. He is the author of THE END OF SEX AND THE FUTURE OF HUMAN REPRODUCTION (Harv. Univ. Press 2016) and CRISPR PEOPLE: THE SCIENCE AND ETHICS OF EDITING HUMANS (MIT Press 2021). Greely graduated from Stanford in 1974 and Yale Law School in 1977. He clerked for Judge John Minor Wisdom of the Fifth Circuit Court of Appeals and Justice Potter Stewart, then served in the Carter Administration's Departments of Defense and Energy. He joined the Stanford faculty in 1985.


 Speaker Profile

PhD, Professor, UCSF Department of Cellular and Molecular Pharmacology, UCSF

Biography
Wendell Lim is a Professor in the UCSF Department of Cellular and Molecular Pharmacology. He serves as the Director of the UCSF Cell Design Institute and the Center for Synthetic Immunology. He completed his A.B. at Harvard University and his Ph.D. at MIT. He was a Postdoctoral Fellow at Yale University. His scientific interests revolve around understanding how genetically encoded molecular programs can produce the remarkable behaviors observed in biological organisms. His lab aims to uncover the fundamental principles governing these molecular programs and how they have evolved. They use synthetic biology and the understanding of molecular networks to engineer cells with novel behaviors, such as therapeutic immune cells programmed to recognize and treat diseases like cancer.


 Speaker Profile

MD, PhD, Clinical Director, Pediatric Immunotherapy Program, UCSF

Biography
Dr. Michelle Hermiston is Professor of Pediatrics at UCSF Benioff Children's Hospital. She research focuses on improving the outcomes for children, adolescents, and young adults with leukemia, lymphoma, and histiocytic disorders. She led development of the Pediatric Immunotherapy Program (including Chimeric Antigen Receptor T cell therapy) from scratch and continues to serve as medical director of this program. Dr. Hermiston also is associate director for education of the Helen Diller Comprehensive Cancer Center Global Cancer Program and site director for their activities in Vietnam where she led development of the first ever Ministry of Health approved training program in Pediatric HematologyOncology. Nationally, she was one of the founding members of the North American Consortium for Histiocytoses (NACHO), currently chairs the Histiocyte Society Langerhans Cell Histiocytosis Committee, and is Vice Chair for the Children's Oncology Group Non Hodgkin Lymphoma Steering Committee where she participates in development and implementation of clinical trials.


 Speaker Profile

PhD, President, CZ Biohub SF

Biography
Dr. Joe DeRisi is a professor of biochemistry and biophysics at UCSF and President at the Chan Zuckerberg Biohub SF, a nonprofit research institute affiliated with UCSF, UCB, and Stanford. Dr. DeRisi specializes in infectious diseases, including viral, fungal, and parasitic microbes, in addition to autoimmune syndromes in humans. He is a member of the NAS, the NAM, and the American Academy of Arts and Sciences.


 Speaker Profile

PhD, Associate Professor/Core Investigator, UCSF/Arc Inst.

Biography
Dr. Luke Gilbert is an esteemed researcher at the UCSF Helen Diller Family Comprehensive Cancer Center and the Arc Institute. Dr. Gilbert's expertise is in synthetic biology, functional genomics and therapeutics. Dr. Gilbert's medical areas of focus are oncology and diseases which can be addressed by genetic medicines such as CRISPR.


 Speaker Profile

PhD, OBE, Director of QB3, UCSF

Biography
Dr. Regis B. Kelly is the Director of QB3, a renowned institute at UCSF that focuses on quantitatively analyzing biological systems. With a distinguished career in neurobiology, Dr. Kelly's research primarily revolved around the molecular mechanisms of neurotransmitter release, a fundamental process of the nervous system. He has held esteemed positions at UCSF, including serving as the Executive Vice Chancellor, and has been recognized with numerous awards for his contributions to science and education. Dr. Kelly's commitment to fostering innovation is evident in his role at QB3, where he supports entrepreneurs and helps translate academic research into realworld solutions. He earned his PhD from Caltech and has been a dedicated educator, mentoring the next generation of scientists and innovators.


 Speaker Profile

PhD, Co-Founder and CSO, Arcadia Science

Biography
Prachee cofounded Arcadia Science, a science company aiming to transform evolutionary innovations into real-world solutions by openly developing more efficient, replicable, and sustainable ways to leverage the biology of diverse organisms. She joined Arcadia from her position as Associate Professor of Biochemistry and Cell Biology at the Geisel School of Medicine at Dartmouth College. Her PhD is in Neuroscience and her academic career was focused on studying the regulation of the ubiquitous cellular antenna, the cilium, using green algae as a model system for which she received the American Society for Cell Biology Junior Award for Excellence in Research. She is also a strong advocate for open science, working to innovate in scientific publishing as a director or advisor of several other organizations including ASAPbio and Astera Institute.


 Speaker Profile

MD, Chief Scientist, UC Berkeley

Biography
Ziad Obermeyer is Associate Professor and Blue Cross of California Distinguished Professor at UC Berkeley. His research uses machine learning to help doctors make better decisions, and help researchers make new discoveries by seeing the world the way algorithms do. His work on algorithmic racial bias has impacted how many organizations build and use algorithms, and how lawmakers and regulators hold AI accountable. He is a cofounder of Nightingale Open Science and Dandelion Health, a Chan Zuckerberg Biohub Investigator, a Faculty Research Fellow at the National Bureau of Economic Research, and was named an Emerging Leader by the National Academy of Medicine. Previously, he was Assistant Professor at Harvard Medical School, and continues to practice emergency medicine in underserved communities.


 Speaker Profile

Ph.D., Chief Science Adviser, PATIO, ARPA-H

Biography
Dr. Arunan Skandarajah leads the emerging technical portfolio for the Project Acceleration and Transition Innovation Office (PATIO) at ARPA-H. PATIO was launched to ensure the success and impact of ARPA-H funded technology, defining success as when it graduates from the agency and survives in the wild, accelerating better health outcomes for everyone. Turning new health technologies into health impact will require innovation in the business and science of healthcare. Arunan is structuring and launching funding opportunities for partners to tackle bottlenecks to successful business models and broad access to solutions.Prior to joining in this role, he supported the stand-up of the agency as a Presidential Innovation Fellow, led outreach efforts for Program Manager candidates, and initiated the agency's partnership with the Food and Drug Administration. He has also developed programs in diagnostics and digital health at the Bill and Melinda Gates Foundation and served as a management consultant.


 Speaker Profile

Ph.D., Chief of the Biosystems and Biomaterials Division (BBD), NIST

Biography
Dr. Sheng Lin-Gibson is a leading expert in biometrology and biotechnology standardization. As the Chief of the NIST Biosystems and Biomaterials Division, she oversees a multidisciplinary research portfolio that includes regenerative medicine and advanced therapies, precision medicine, synthetic biology, complex microbial systems, and emerging biomanufacturing technologies. She leads and coordinates the development of global standards for emerging biotechnology, including advanced therapy and precision medicine. She has coauthored over 80 peer-reviewed publications, serves on many Interagency Working Groups as well as numerous expert review panels and advisory boards. She has received several Department of Commerce Gold Medals.


 Speaker Profile

MD, PhD, Assistant Director, NSF

Biography
Marqusee is a Distinguished Professor of Molecular and Cell Biology and Chemistry at the University of California, Berkeley, and a Chan Zuckerberg Biohub Investigator. From 2010-2020, she served as the director for the California Institute of Quantitative Biosciences, or QB3, at UC Berkeley. Marqusee earned numerous awards honors, including the Margaret Dayhoff Award from the Biophysical Society, the William Rose Award from the American Society for Biochemistry and Molecular Biology, and the Dorothy Crowfoot Hodgkin Award from The Protein Society. She is a fellow of both the Biophysical Society and the American Society for Biochemistry and Molecular Biology, and an elected member of the American Academy of Arts and Sciences (2013) and the National Academy of Sciences (2016).


 Speaker Profile

M.D., Pediatric Oncologist, Stanford

Biography
I am a pediatric oncologist actively pursuing immunotherapy research with a focus on translating cellular therapies. In the laboratory, I engaged in CAR T cell engineering and studies of T cell subset optimization for adoptive transfer. I lead early phase clinical trials studying alternatives to CD19-monospecific targeting, including bispecific CAR and CD22 CAR development, and am a co-investigator studying GD2-specific CAR T cell therapy for fatal brainstem tumors. In efforts to expand our knowledge of real world performance of CAR T cell therapy, I founded and chair the Pediatric Real-world CAR Consortium (PRWCC), a consortium with 38 participating core institutions and a mission to foster collaboration and create a forum for multi-institutional data and sample sharing. This is a growing collaborative network that is poised towards advancing outcomes following immunotherapy for pediatric cancers.


 Speaker Profile

Ph.D., MPH, Associate Professor, Department of Social & Behavioral Sciences, UCSF

Biography
Sara Ackerman is a medical anthropologist working in the interdisciplinary fields of empirical bioethics and implementation science. Her research draws on ethnographic methods to examine social, ethical and equity issues in emerging precision medicine initiatives. Dr. Ackerman, along with her team at the UCSF Clinical and Translational Science Institutes Regulatory Knowledge and Support Program, is working to increase community participation in decisions about how health data is shared and used. She also teaches three courses at UCSF: Community-Engaged Research, Qualitative Methods, and Responsible Conduct of Research. Dr. Ackerman has received several honors, including the Diana Forsythe Award from the American Medical Informatics Association in 2013.


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