Session Abstract – PMWC 2022 Silicon Valley

 Session Chair Profile

Ph.D., Executive Vice President and Head of R&D, Lava Therapeutics

Biography
Prof. Paul W.H.I. Parren is dedicated to translating antibody biology and immunotherapy knowledge into innovative therapeutics and technologies. He holds a PhD in molecular immunology from the University of Amsterdam (1992). Prof. Parren was an Associate Professor at The Scripps Research Institute in La Jolla, California. From 2002-2017, he led research and preclinical development at Genmab, leading to seven product approvals to date. He is an inventor of ofatumumab (Arzerra, 2009; KESIMPTA, 2020), daratumumab (DARZALEX, 2015, DARZALEX-Faspro, 2021), teprotumumab (Tepezza, 2020), amivantamab (RYBREVANT, 2021), tisotumab vedotin (Tivdak, 2021) and two clinically translated technologies to generate bispecific (DuoBody) and effector-function enhanced (HexaBody) antibodies. In 2015, he became a Professor of Molecular Immunology at the Leiden University Medical Center in Leiden. In 2018, he joined LAVA Therapeutics, a biotechnology company focused on developing bispecific gamma-delta T cell engagers to transform cancer therapy, as its Executive Vice President and Head of R&D.


 Speaker Profile

M.D., Ph.D., Professor at UCSF and SVP at Sana Biotechnology

Biography
Work by Dr. Sonja Schrepfer is at the forefront of stem immunobiology and paves the way for treatment of a wide range of diseases – from supporting functional recovery of failing myocardium to the derivation of other cell types to treat diabetes, blindness, cancer, lung, neurodegenerative, and related diseases. Her work demonstrates that protecting transplanted cells from immune rejection is the key to unlocking the potential of regenerative medicine. Dr. Schrepfer is Professor at the University of California San Francisco (UCSF), Gladstone-UCSF Institute of Genomic Immunology, and a Scientific Founder and SVP (Head of the Hypoimmune Platform) of Sana Biotechnology, Inc.


 Speaker Profile

Ph.D., Senior Director / Principal Scientist, Genentech

Biography
Greg Lazar received his BS in Molecular & Cell Biology and Chemistry from Penn State, his PhD in Molecular & Cell Biology from the University of California at Berkeley, and did postdoctoral research at the University of Cambridge, UK. Previously he led research groups at Eli Lilly and Xencor. Currently he is Senior Director and Principal Scientist in Antibody Engineering at Genentech. Dr. Lazar is an expert in biotherapeutic engineering and drug discovery, and has developed technologies and molecules that have led to 3 approved drugs and over 10 candidates across all stages of clinical trials. He has authored 40 scientific publications and is an inventor of over 30 patents. His current research focus is the development of novel antibody technologies to enable next generation therapeutics to treat unmet medical needs in oncology and neuroscience.