Session Abstract – PMWC 2021 Silicon Valley


Early cancer detection biomarkers – single and multi cancers | single and multi analytes - are still in the early phases of development. Before these types of biomarkers/tests can be used in the clinical setting, various clinical and preclinical issues (e.g. detection sensitivity) need to be addressed. This session discusses latest advancements in the development of these biomarkers and describes clinical study programs in which they are implemented, including the limitations and challenges that need to be overcome before the translation of their use for clinical purpose will be a reality.

 Session Chair Profile

M.D., Ph.D., Chief Scientific Officer, Freenome

Biography
In his role as Freenome’s Chief Scientific Officer, Jimmy is responsible for our scientific strategy, research operations, and growing the company’s world-class scientific team. He brings a proven record of translating cutting-edge research into commercial success, with a focus on the development and launch of blood-based assays for cancer monitoring and detection of molecular residual disease. Prior to joining the private sector, as CSO for Oncology at Natera, the global genomic diagnostics company, Dr. Lin led the intramural clinical genomics program at the National Cancer Institute at the National Institutes of Health. At Johns Hopkins and Washington University in St Louis, he spearheaded the computational analyses of the first-ever exome sequencing studies in multiple cancer types. Dr. Lin holds an MD and a PhD in Cellular and Molecular Medicine from Johns Hopkins School of Medicine, as well as a Master of Health Sciences in Bioinformatics from Johns Hopkins School of Public Health. As an undergraduate at Yale, he majored in Cognitive Science and Molecular Biophysics & Biochemistry. Dr. Lin was a 2016 Senior TED Fellow and is the Founder and President of the Rare Genomics Institute.


 Speaker Profile

M.D., Ph.D., Assistant Professor of Medicine (Oncology), Stanford

Biography
The major focus of Dr. Alizadeh’s research group is to attain a better understanding of the initiation, maintenance, and progression of lymphoid tumors, and their response to existing and novel therapies toward improving current treatment strategies. In this effort, they employ tools from functional genomics, computational biology, molecular genetics, and mouse models. They hope to apply this knowledge towards the design of clinical trials in the treatment of patients with lymphoma, leukemia, and myeloma.


 Speaker Profile

CEO, Thrive Earlier Detection Corp.

Biography
Dave brings to Thrive more than 25 years of diagnostics expertise in significant executive leadership roles in both startup and large-scale organizations. He currently serves as the Chief Executive Officer and Board Member for Thrive Earlier Detection. Prior to Thrive, he served as senior vice president and general manager of commercial operation for the Americas region at Illumina. There, Dave was responsible for all regional commercial functions, including sales, sales support, marketing, field service, technical support and field applications. Prior to joining Illumina, Dave was the chief commercial officer of Foundation Medicine, a company dedicated to transforming cancer care by identifying molecular alterations in each patient’s unique cancer and matching them with potential targeted therapies and immunotherapies. There, he led all commercial functions globally, including sales, marketing, client services, payer relations and medical affairs. Before that, Dave lead the oncology business unit at Life Technologies, responsible for the establishment of a clinical oncology strategy, centered on a central lab services model providing support to both research and clinical customers. After Thermo Fisher acquired Life Technologies, he transitioned to Thermo’s anatomic pathology division, where he oversaw all commercial operations globally.