Session Abstract – PMWC 2022 Silicon Valley

Track 5, June 29


Early cancer detection technologies have huge potentials to change disease outcome and patient management, yet most of these technologies are still in development. This session discusses latest technological and clinical advancements, clinical limitations and challenges to overcome, and the potential for future applications using the various types of early detection biomarkers.

 Session Chair Profile

M.D., Ph.D., Chief Scientific Officer, Freenome

Biography
Jimmy Lin, MD, Ph.D., MHS was the Chief Scientific Officer (CSO), Oncology at Natera (NASDAQ: NTRA), where he lead the development of new diagnostic technologies for cancer. Dr. Lin is also a 2016 Senior TED Fellow and Founder & President of Rare Genomics Institute, the world's first platform to enable any community to leverage cutting- edge biotechnology to advance understanding of any rare disease. Previously, Dr. Lin led the ClinOmics program in the Genetics Branch of the National Cancer Institute (NIH/NCI). Before this, he led the computational analysis of the first-ever exome sequencing studies of cancer at Johns Hopkins and was a research instructor at Washington University in St. Louis. He has numerous publications in Science, Nature, Cell, Nature Genetics, and Nature Biotechnology, and has been featured in Forbes, Bloomberg, Wall Street Journal, New York Times, Washington Post, BBC, TIME, and the Huffington Post.


 Session Chair Profile

M.D., Ph.D., Assistant Professor of Medicine (Oncology), Stanford

Biography
The major focus of Dr. Alizadeh’s research group is to attain a better understanding of the initiation, maintenance, and progression of lymphoid tumors, and their response to existing and novel therapies toward improving current treatment strategies. In this effort, they employ tools from functional genomics, computational biology, molecular genetics, and mouse models. They hope to apply this knowledge towards the design of clinical trials in the treatment of patients with lymphoma, leukemia, and myeloma.


 Speaker Profile

Ph.D., Co-Founder & Co-CEO, Guardant Health

Biography
AmirAli Talasaz currently serves as co-founder and co-CEO of Guardant Health, a leading precision oncology company. AmirAli is an entrepreneur in the rare genomics and clinical diagnostics fields. Prior to co-founding Guardant Health, he was Senior Director of Diagnostics Research at Illumina and led the efforts for emerging clinical applications of next-generation genomic analysis. During that time, he developed different genomic technologies suitable for clinical applications. Before Illumina, he founded Auriphex Biosciences, which focused on purification and genetic analysis of circulating tumor cells for cancer management. The technology was acquired by Illumina in 2009. During his academic years, he led the Technology Development group at Stanford Genome Technology Center. AmirAli received his PhD in electrical engineering and MSc in management science from Stanford University.


 Speaker Profile

Ph.D., Chief Scientific Officer, Delfi Diagnostics

Biography
Nicholas Dracopoli joined Delfi Diagnostics in 2019. Previously he was Vice President, Head Oncology Translational Research and Oncology Diagnostics at Janssen R&D and, before that, Vice President of Clinical Discovery Technologies at Bristol-Myers Squibb. Prior to joining the pharmaceutical industry, he spent five years in the biotechnology industry at Sequana Therapeutics. Dr Dracopoli obtained his B.Sc. and Ph.D. degrees from the University of London, and completed post-doctoral fellowships at the Memorial Sloan-Kettering Cancer Center and the Massachusetts Institute of Technology. Subsequently, he served as an Assistant Director at the Whitehead/MIT Genome Center, and as a Section Chief at the National Center for Human Genome Research at the NIH before moving to the biotechnology industry. Dr Dracopoli has authored >70 scientific publications, and has extensive experience in the fields of genomics, molecular biology and cancer research.


 Speaker Profile

M.D., Chief Medical Officer, Adela Inc.

Biography
Dr. Hartman is a highly trained medical oncologist with 15 years of industry experience in product development with expertise in the clinical development and commercialization of molecular diagnostics in cancer screening and oncology. With an interest in innovative technology platforms to improve patient outcomes and health care, Dr. Hartman has played a pivotal role in the development and commercialization of several molecular diagnostic tests in oncology. This includes leading the design and completion of several large scale clinical trials in early cancer detection and hereditary cancer screening. Her interest in innovative technology ultimately led her to co-found Adela to develop a best-in-class liquid biopsy test for early cancer detection and minimal residual disease detection that avoids the limitations of standard liquid biopsy approaches.

Talk
Multi-Cancer Screening Using Adela’s Methylome Profiling Platform
cfMeDIP-seq is a next-generation methylation technology being developed for applications across the cancer care continuum. Technical advantages enable high sensitivity for cancer detection, tissue of origin, histologic subtyping , and identification of underlying biology through distinct patterns of methylation across the cancer methylome.