Session Abstract – PMWC 2022 Silicon Valley

 Speaker Profile

Ph.D., Head of Science, Seven.me

Biography
Dr. Jennifer Lovejoy is a senior executive and biobehavioral scientist with deep experience in personalized medicine. During her academic career, Dr. Lovejoy held the Manship Endowed Professorship in Diabetes at LSU's Pennington Biomedical Research Center. She is a Past-President of the Obesity Society and has published over 80 peer-reviewed papers on her research. More recently, Dr. Lovejoy was Chief Translational Science Officer at Arivale, a precision medicine startup uniting systems biology and behavioral science to help consumers optimize wellness. Currently, she works at Seven.me, a digital health startup developing a unique behavioral AI platform combined with coaching and rapid at-home blood testing to help consumers transform their health.


 Speaker Profile

M.D., Boyd Professor Emeritus, Pennington Biomedical Research Center

Biography
George A. Bray, M.D., founded the International Journal of Obesity in 1976, Chaired the 2nd International Congress on Obesity in 1977, founded the Obesity Society (NAASO) in 1981 and the journal Obesity in 1993. In 1989 he became the 1st Executive Director of the Pennington Biomedical Research Center. Among his many awards is the Presidential Medal from The Obesity Society and the 2019 Wilbur O Atwater Award from the USDA and ASN. Bray authored than 1,000 publications.

Talk
Lessons Learned from the POUNDS Lost Study
The POUNDS Lost study measured weight loss in 811 individuals assigned to 20% or 40% fat and 15% and 25% protein diets. Weight loss was not different between diet but there was a large variance. This study provides many lesson on interaction of diet with genetic and non-genetic factors.


 Speaker Profile

Ph.D., Rehnborg Farquhar Professor of Medicine, Stanford University

Biography
For ~30 years Christopher Gardner has studied what to consume and to avoid for optimal health, and how best to motivate individuals to achieve healthy dietary behaviors. Some of the dozens of human nutrition intervention trials he has conducted include studies of garlic, omega-3 fats, soy phytoestrogens and antioxidants. Among his most cited studies are the A TO Z (JAMA 2007) and the DIETFITS (JAMA 2018) weight loss diet trials. The DIETFITS trial examined the possibility that a 3-SNP multilocus genotype would predict differential weight loss success on a Healthy-Low-Fat vs. a Healthy-Low-Carb diet among more than 600 overweight and obese adults. His interests in this area of personalized nutrition continue with his participation in the Trans-NIH Consortium: Randomized Controlled Trials of Lifestyle Weight Loss Interventions for Genome-wide Association Studies. He is also working on personalized nutrition explorations with other investigators.

Talk
DNA-based Weight Loss Interventions: What Have We Learned?
The 2018 DIETFITS study tested the hypothesis that a 3-SNP genotype pattern would be an effect modifier of weight loss on a healthy low-fat vs. a healthy low-carb diet. The hypothesis was not supported. NIH convened a consortium too look at this question across studies. What have they learned?