Session Abstract – PMWC 2020 Silicon Valley

Dr. Yuryev introduces Elsevier biomedical knowledge graph and its applications for per-sonalized medicine. Dr. Castillos describes how Elsevier technology is integrated at WakeMed, including clinical paths, payment options, success rates based on five-year ex-perience in using affordable personalized drug therapy selection for advanced cancer pa-tients.

 Session Chair Profile

Ph.D., Professional Services Director, Elsevier

Dr. Anton Yuryev discovered proteins physically linking gene transcription and mRNA processing in eukaryotic cells during Johns Hopkins University graduate program in 1995. He worked over 30 years in bioinformatics as Senior Scientist at InforMax, Senior Bioinformatics Analyst at Orchid Cellmark, and Application Science Director at Ariadne Genomics founded by him in 2003. Dr. Yuryev has published over 50 scientific articles, edited four books, algorithms for primer design, pathway and network analysis. After Ariadne Genomics acquisition by Elsevier Dr. Yuryev works as a Professional Services Director at Elsevier. He develops dedicated bioinformatics solutions using Elsevier software, knowledgebases and artificial intelligence in areas of drug development, personalized medicine, agro- and synthetic biology. Dr. Yuryev’s interests involve statistical modeling for drug repurposing, drug target prioritization, and therapy optimization for individual patients utilizing knowledge about molecular mechanisms of all human malignancies including rare diseases and cancers extracted from scientific literature.

 Speaker Profile

M.D., Personalized Hematology/Oncology of Wake Forest

Dr. Francisco Castillos is a Hematology/Oncology specialist in Wake Forest, NC and has been practicing for 20 years. He graduated from Chicago Medical School in 1995 and is board-certified in Internal Medicine, Oncology, and Hematology. He served with the 1st Marine Division for Alpha Surgical Company during Operation Iraqi Freedom, 1st FSSG, in 2003 as a Lieutenant Commander in the Navy. He is owner of Personalized Hematology/Oncology of Wake Forest, PLLC and focused on personalized medicine and efficient quality care. We utilize gene expression profiling to deliver optimal, safe, and cost-effective chemotherapy/molecularly targeted treatments, while ensuring that adult cancer patients are not under treated or over treated.

Using Personalized Medicine to Cure Metastatic Cancer
Used fresh tissue biopsies placed in RNA-later, mRNA extraction for high purity RNA, Affymetrix gene chip produced; used Pathway Studio (Elsevier) to analyze GEP, which provides molecularly targeted drugs to block the predominant signal transduction pathways for an individual’s cancer — stage IV patients remain in clinical remission using this approach.