Stephen Kingsmore, President & CEO of Rady Children’s Institute for Genomic Medicine, is a household name for fast diagnosis and treatment of critically ill newborns. Applying whole genome sequencing (WGS) in Newborn Intensive Care Units (NICUs) to diagnose critically ill newborns via fast data analysis has resulted in success stories that were unthinkable just a few years ago. Clearly, WGS is revolutionizing the field of rare disease diagnosis and none of this would be possible without the underlying technological advancements. Kingsmore has applied his vision of translating these advancements into something deeply meaningful– saving the lives of newborns.

Combining different technologies and applying them to the critical need of an expedited diagnosis (within 25 hours) for newborns who are struggling to hold on to life, sounds like a straightforward task. But like most aspects of medicine, the real complexity reveals itself in the implementation.

Today Kingsmore and Rady Children’s Hospital’s implemented clinical workflow is considered the exemplary leader in pediatric genomic medicine, an example that is likely to become a model, not only for other NICUs, but for efficient whole genome sequencing in the general clinical setting. Panel sequencing in the clinical setting is an established approach, but WGS applications are lagging, mostly due to interpretation limitations. Rapid clinical WGS, however, is imperative in light of growing evidence of its utility in acute care, such as in diagnosis of genetic diseases in very ill infants, and genotype-guided choice of chemotherapy at cancer relapse. This is especially true in situations when delayed clinical decisions may mean the difference between life and death.

We are delighted to have Dr. Stephen Kingsmore join us at PMWC 2018 Silicon Valley in January, to share his vision of WGS, genomic medicine in healthcare, how he’s promoting WGS, and how we can translate some of his learnings into other applications.

In order to successfully achieve acceptance and uptake of WGS in the clinic we need secure, scalable, and fast solutions, in addition to knowledge extraction tools that diagnose and explain a disease, or help make decisions regarding the correct treatment choice. We have several sessions planned that address exactly these needs – here a few highlights:

  • Scalable NGS infrastructure/platforms
    • Scalable infrastructure/platforms integrating NGS and other data to power discovery and analysis in Pharma and the clinic – with session chair Brady Davis of DNAnexus
  • Expediting the analysis of clinical NGS data
    • Advancing clinical next-generation sequencing, chaired by Rebecca Hemenway of Edico Genome
      • Presenter: Alex Bisignano (Phosphorus), Bruce Quinn (Bruce Quinn Associates), Melanie Nallicheri (Foundation Medicine)
    • Expediting patient diagnosis and treatment with AI and machine learning with chair Eric Schadt of Sema4
      • Presenter: Jessica Meg (Verily), Thomas Wilckens (InnVentis), Jurgi Camblong (Sophia Genetics)
  • NGS Data analysis solutions
    • Applying machine learning to deliver value for a range of healthcare stakeholders, chaired by Diane Wuest of GNS Healthcare
    • The challenges and rewards of bringing AI into the clinic for health & disease management with chair Chris Cournoyer of N-of-One
      • Presenters: Yarmela Pavlovic (Hogan Lovells), Jeff Boyd (Baptist Health South Florida), Sheryl Elkin (N-of-One), Andrew Beck (PathAI)
    • How AI will Cure Cancer chaired by Marty Tenenbaum of Cancer Commons
    • Delivering laboratory reports that translate into clinical actions for oncologists, which is chaired by John Shon of Illumina
      • Presenters: Richard Schilsky (ASCO), Lincoln Nadauld (Intermountain)
    • State of genomics-guided clinical decision support, chaired by Sean Scott of Qiagen
      • Presenter: Raju Pillai (City of Hope National Medical Center), Alejandro Sweet-Cordero (UCSF)
    • Enabling precision medicine through automated literature analysis with chair Mark Kiel of Genomenon
  • Precision Medicine + All of Us Research Program
    • An entire track that focuses on large scale whole genome initiatives– the learnings, the challenges, and the needs
      • Biospecimens as building blocks for precision medicine discovery, with chair Chris Ianelli, iSpecimen
      • AACR Project GENIE: An international Cancer Registry. Chair: Alexander Baras, Johns Hopkins Hospital
      • Data sharing & protection with Hector Rodriguez, Microsoft
      • Precision medicine initiative status in Germany with Erwin P. Bottinger, Hasso-Plattner-Institute GmbH
      • All of Us Research Program Sessions with chair Stephanie Devaney, NIH
      • Large scale sequencing and genetics initiatives with chair Aris Baras, Regeneron
      • An update from the California PM initiative with chair India Hook-Barnard, UCSF
  • Find the full program with all speakers here.

We also have a series of Company Showcases that highlight exciting commercial developments in whole genome NGS solutions, including:

  • Wellness and Aging
  • Emerging Therapeutics
  • Microbial
  • Clinical Dx
  • Liquid Biopsy
  • AI / Machine Learning
  • Immunotherapy
  • Genomic Profiling

Don’t miss out. Join us January 22 – 24 at the Computer History Museum in the heart of the Silicon Valley, for PMWC 2018 SV.

Join us now!

Call to the Health Care Community to Execute on Next Steps for a Wider Adoption and Implementation of Precision Medicine

The recent Facebook data breach, genetic data sleuthing by the FBI that led to the Golden State Killer, and the soon-to-be-implemented European General Data Protection Regulation (GDPR), has put data privacy and security front and center.

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Data Privacy, the Security, And Ownership

The recent Facebook data breach, genetic data sleuthing by the FBI that led to the Golden State Killer, and the soon-to-be-implemented European General Data Protection Regulation (GDPR), has put data privacy and security front and center.

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Q&A with Jason Crites from IBM & Piers Nash from Health2047 Speaking at PMWC 2018 Michigan in June

Q: What need is IBM and Health2047 addressing in the healthcare/life sciences sector?

Jason (IBM): The industry is undergoing a significant transformation as reimbursement shifts from fee-for-service to value-based outcomes in the face of regulatory uncertainty.

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Dr. Francis Collins of NIH at June PMWC Michigan- Launch of Nationwide Participation Enrollment!

This past Sunday—May 6, 2018—the program reached a major milestone with the start of the nationwide participation enrollment! The All of Us Research Program, part of the Precision Medicine Initiative that was famously announced by President Barack Obama at the 2015 State of the Union address, aims to enroll a total of 1 million Americans.

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Meet Dr. Gil Omenn, Director of the University of Michigan Center for Computational Medicine & Bioinformatics on June 6th at PMWC 2018 Michigan

Q: What are the objectives of the Human Proteome Project and what are some of the recent breakthrough discoveries?

The HUPO Human Proteome Project has two overarching goals: (1) to complete the protein parts list, with at least one protein product from each of the ~20,000 protein-coding genes along with sequence variants, splice variants, and post-translational modifications, with characterization of their functions;…

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Meet Amir Dan Rubin, CEO of One Medical on June 6th at PMWC 2018 Michigan

Q: What are some of the biggest contributors to these challenges and how can we overcome them?

A: One of the underlying challenges driving the rising the cost of health care is that most of the health system’s stakeholders have few incentives, if not outright disincentives, to manage expenditures.

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Interview with Steve Nelson, CEO, UnitedHealthcare Presenting at PMWC 2018 Michigan in June

Q: What’s the biggest misconception about UnitedHealthcare?

That we don’t care, that we’re just a health insurance company that pays or denies medical claims. In reality, helping people is at the core of what we do every day.

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Emerging Technologies are Disrupting Healthcare | PMWC Michigan June 6-7

We had the chance to sit down with Dr. Topol to hear his thoughts on big data, digital health, sensors, and artificial intelligence, some of the newest precision medicine technologies.

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Interview with Dan Rhodes from Strata Oncology

Q: What need is Strata Oncology addressing?

Despite substantial advances in precision oncology, the majority of advanced cancer patients still do not benefit from comprehensive tumor molecular profiling or precision therapy trials.

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Interview with Lisa McLaughlin from Workit Health

Q: What need is Workit Health addressing?

Drug overdoses killed more Americans last year than were lost during the entire Vietnam War (69,000).

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Interview with Olivier Elemento from Weill Cornell Medicine

Q: What research are you or your lab focusing on and why, and what problem(s) are you trying to solve?

I direct the Englander Institute for Precision Medicine, an Institute that focuses on using genomics and informatics to make medicine more individualized.

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Interview with Dr. Dunnenberger from NorthShore University HealthSystem

Q: What patient population is NorthShore University HealthSystem serving and which services are you specializing in?

NorthShore is a four hospital community health system with over 100 outpatient medical offices.

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How Artificial Intelligence (AI) Will Potentiate Individualized Medicine, Q&A with Eric Topol

We had the chance to sit down with Dr. Topol to hear his thoughts on big data, digital health, sensors, and artificial intelligence, some of the newest precision medicine technologies.

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Interview with Jennifer Kloke from Ayasdi

Q: What need is Ayasdi addressing?

Ayasdi is pioneering the application of AI to value-based care by targeting two of the most complex problems in healthcare: population risk stratification and clinical variation management.

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Q&A with Eric Topol, Executive Vice President, Scripps Research Institute

Dr. Eric Topol, voted by Modern Healthcare as the most influential physician executive in the United States, shared his thoughts on why people should own and control their own data.

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University of Michigan

The Precision Medicine World Conference (PMWC), held annually in Silicon Valley, is coming back to North Carolina for its 2nd Conference back at Duke University on September 24-25, 2018.

PMWC 2018 Duke, the 15th installment of the conference, will spotlight the explosion of biomedical technologies, driving initiatives that enable the translation of precision medicine into direct improvements in health care.

 

  • Track 1 will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
    • Digital Phenotyping
    • Precision Public Health
    • Pharmacogenomics
    • The Microbiome
    • Rare Disease Diagnosis
    • Digital Health/Health and Wellness
    • Early Days of Life Sequencing
    • Diversity in Precision Medicine
    • Resilience
    • AI and Machine Learning
    • Gene Editing
    • Large Scale Bio-data Resources to Support Drug Development (PPPs)
    • Point-of Care Dx Platform
    • FDA Efforts to Accelerate PM
    • Implementation into Health Care Delivery
    • Next Gen. Workforce of PM
    • Immunotherapy
    • Robust Clinical Decision Support Tools
    • Creating Clinical Value with Liquid Biopsy ctDNA, etc.
    • Neoantigens
    • Emerging Technologies In PM

The Precision Medicine World Conference (PMWC), held annually in Silicon Valley, is coming back to North Carolina for its 2nd Conference back at Duke University on September 24-25, 2018.

PMWC 2018 Duke, the 15th installment of the conference, will spotlight the explosion of biomedical technologies, driving initiatives that enable the translation of precision medicine into direct improvements in health care.

 

    • Track 1 will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
      • Digital Phenotyping
      • Precision Public Health
      • Pharmacogenomics
      • The Microbiome
      • Rare Disease Diagnosis
      • Digital Health/Health and Wellness
      • Early Days of Life Sequencing
      • Diversity in Precision Medicine
      • Resilience
      • AI and Machine Learning
      • Gene Editing
      • Large Scale Bio-data Resources
        to Support Drug Development (PPPs)
      • Point-of Care Dx Platform
      • FDA Efforts to Accelerate PM
      • Implementation into Health Care Delivery
      • Next Gen. Workforce of PM
      • Immunotherapy
      • Robust Clinical Decision Support Tools
      • Creating Clinical Value with Liquid Biopsy
        ctDNA, etc.
      • Neoantigens
      • Emerging Technologies In PM
  • Track 2- PMWC 2018 Duke Showcase, will enable 15-minute company presentations on latest novel technologies. Apply to present here.
big data diagnostics session

Clinical Dx Showcase

crispr showcase

Emerging Therapeutics Showcase

NGS Showcase

Genomic Profiling Showcase

AI Showcase Session Image

AI and Data Sciences Showcase

  • Luminary and Pioneer Awards, honoring individuals who contributed, and continue to contribute, to the field of Precision Medicine
  • 500+ multidisciplinary attendees, from across the entire spectrum of healthcare, representing different types of companies, technologies, and medical centers with leadership roles in precision medicine

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