John Mattick was recently appointed Chief Executive of Genomics England. He was previously the Director of the Garvan Institute of Medical Research in Sydney, where he established one of the first clinically accredited genome analysis enterprises. He was the Foundation Director of the Australian Genome Research Facility and the Institute for Molecular Bioscience at the University of Queensland. He is well known for his work showing that the majority of the human genome is not junk but specifies an RNA-based regulatory system that organizes the epigenetic trajectories of development. His honors include Fellowship of the Australian Academies of Science and Technology & Engineering, Foreign Membership of the European Molecular Biology Organization, Honorary Fellowship of the Royal College of Pathologists of Australasia, the Human Genome Organization Chen Award for Distinguished Achievement in Human Genomic Research, and the University of Texas MD Anderson Center Bertner Award for Distinguished Contributions to Cancer Research.