ERIC TOPOL

PMWC LUMINARY AWARD
Pioneered genetics & genomics in cardiovascular medicine and led the era of wireless medicine
M.D., Executive VP & Professor, Molecular Medicine, The Scripps Research Institute

Dr. Eric Topol, voted by a Modern Healthcare national poll as the most influential physician executive in the US, will present & be honored at the Precision Medicine World Conference PMWC 2018 Michigan June 6-7.

We had the chance to sit down with Dr. Topol to hear his thoughts on big data, digital health, sensors, and artificial intelligence, some of the newest precision medicine technologies.

Here’s a part of that conversation. See the full interview

We discussed major challenges for these tools to potentiate individualized medicine.

  • Data Ownership: Our number one problem today is the inability for people to have all of their data. No one has all that data, unlike places like Estonia and other countries where patients have and own all that data. To maximize the data’s impact a vital flip must occur. Instead of health systems and doctors owning the data, people need to own their data. And patients will very happily share that data with specific health providers, doctors, and others.
  • Analysis: What we have today is lots of in silico analysis and retrospective validation, but that is not good enough to change medicine. We need to see all of these things, whether it is retinal diagnosis, an EKG, or a heart arrhythmia, any type of medical scan, cancer pathology slides, or skin lesions—validated prospectively so that the medical community can accept it. None of this has been done to date.
  • Security & Privacy: The seemingly endless sea of data breaches we hear about across industries – whether it be Facebook or MyFitnessPal – cannot be tolerated in the medical world. This is another reason why people have to own their data and on a secure platform, like Blockchain or a private cloud. Massive data servers are incredibly attractive to cyber thieves and hackers and medical data sells for 5-fold more than personal financial data on the Dark Web.

Dr. Topol’s keynote at PMWC Michigan, “The Future of Individualized Medicine”, addresses these challenges.

In addition, PMWC Michigan will include a number of sessions dedicated to data such as:

  • “The Promise of Precision Medicine for All of Us”
    Francis Collins (National Institutes of Health – NIH)
  • “Transforming Big Data Into Actionable Information”
    Nancy Cox (Vanderbilt University), Eric Lefkofsky (Tempus), Michael Boehnke (UMich), Anil Sethi (Ciitizen), Goncalo Abecasis (UMich) and Isaac Kohane (Harvard)
  • “Better Health Outcomes via Knowledge Networks, AI, and Technical Innovation”
    India Hook-Barnard (UCSF), Pratik Mukherjee (UCSF), and Shelly Greenfield (UC Irvine) among other thought leaders
  • AI and Data Sciences Showcase
    Arcascope, Athelas, Ayasdi, Ciitizen, Data4Cure, DataSpeaks, Genomatix, Genomenon, IBM Watson Health, iNDx Technology, IQVIA, ISAAC Corp, Henry Ford Health System, Medical College of Wisconsin, Mendel.ia, Parabricks, University of Windsor, Wayne State University
  • Health Monitoring Showcase
    Arborsense among others
  • Wellness and Aging Showcase
    JOOL Health and VA Ann Arbor Health System, among others

This is a great opportunity for everyone in the field to engage in important discussions on data sharing, data ownership, creating prospective algorithms, and data security/privacy, all of which will impact the future of individualized medicine.

Looking forward to seeing many of you at the upcoming PMWC 2018 Michigan conference scheduled for June 6-7, Ann Arbor, MI.

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A: To explain the uniqueness of the Maccabi Biobank (named “Tipa” in Hebrew which means “drop” or “just a little”), first you must know a little about Maccabi.

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Why We Need Public-Private Partnerships (PPP) To Foster Drug Discovery

Investments in pharma R&D has substantially increased over the last decades. Yet there appears to be no clear correlation to the number of newly approved drugs. This fact is accompanied by ever-increasing healthcare costs, fueled by an aging population and the parallel rise in the chronic disease burden.

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Interview with David Hong from Karius

Q: What need is Karius addressing?

A: Physicians often have difficulty pinpointing the exact pathogen that is causing disease. Conventional diagnostics like blood cultures or PCR can have poor sensitivity due to pretreatment with antibiotics, the breadth of potential pathogens present, and the requirement for invasive procedures to access deep-seated infections.

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Interview with Charles Jaffe, MD, PhD from HL7

Q: What need is HL7 addressing?

A: For more than three decades, HL7 has provided the platform to enable global health data interoperability. This is more important than ever, as the cost of healthcare has increased exponentially, and the complexity of clinical evidence has grown to an almost unmanageable state.

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Interview with Eden Haverfield from Invitae

Q: What need is Invitae addressing?

A: Our mission is to bring comprehensive genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. Invitae is uniquely positioned to answer some of life’s most serious and complex questions with the highest quality genetics and at an affordable price.

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Call by Ralph Snyderman (Duke U.) for Big Changes to Get to the Next Level of Precision Medicine

Beyond next-generation gene sequencing and developing diagnostic tools and targeted therapies, theoverall approach to clinical care has to be re-envisioned to fulfill the promise of precision medicine. Care must move from sporadic treatment of episodic disease (a reactive mode) to predicting disease and then acting to prevent and mitigate it (a proactive mode).

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Interview with William Hearl From Immunomic Therapeutics, Inc.

Q: What need is Immunomic Therapeutics, Inc. addressing?

A: Immunomic Therapeutics’ nucleic acid vaccines have the potential to utilize the body’s natural biochemistry to develop a broad immune response, including antibody production, cytokine release and critical immunological memory.

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Interview with Ralph Snyderman from Duke University

Q: What are some of the critical contributions that academic institutions and medical centers are making to implement and accelerate precision medicine?

A: Over the past decade, the field of precision medicine has created technologies enabling far more personalized and effective health care delivery. Many of the most dramatic advances have come in the field of oncology but targeting care to the needs of the individual is rapidly achieving broader applications.

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Interview with Catherine Reinis Lucey from UCSF

Q: What research are you or your lab focusing on and why, and what problem(s) are you trying to solve?

A: My work involves designing, implementing and studying innovations in medical education that allow our medical schools to fulfill our social contract to improve the health of our communities and reduce the suffering of our patients.

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Interview with Gunnar Carlsson from Ayasdi

Q: What need is Ayasdi addressing?

A: Ayasdi is pioneering the application of artificial intelligence to value-based care by targeting two of the most complex problems in healthcare: population risk stratification and clinical variation management.

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Interview with Nikole Kimes from Siolta Therapeutics

Q: What need is Siolta Therapeutics addressing?

A: Chronic diseases, including inflammatory diseases such as asthma, now represent the leading cause of mortality and morbidity worldwide.

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University of Michigan

The Precision Medicine World Conference (PMWC), held annually in Silicon Valley, is coming back to North Carolina for its 2nd Conference back at Duke University on September 24-25, 2018.

PMWC 2018 Duke, the 15th installment of the conference, will spotlight the explosion of biomedical technologies, driving initiatives that enable the translation of precision medicine into direct improvements in health care.

 

  • Track 1 will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
    • Digital Phenotyping
    • Precision Public Health
    • Pharmacogenomics
    • The Microbiome
    • Rare Disease Diagnosis
    • Digital Health/Health and Wellness
    • Early Days of Life Sequencing
    • Diversity in Precision Medicine
    • Resilience
    • AI and Machine Learning
    • Gene Editing
    • Large Scale Bio-data Resources to Support Drug Development (PPPs)
    • Point-of Care Dx Platform
    • FDA Efforts to Accelerate PM
    • Implementation into Health Care Delivery
    • Next Gen. Workforce of PM
    • Immunotherapy
    • Robust Clinical Decision Support Tools
    • Creating Clinical Value with Liquid Biopsy ctDNA, etc.
    • Neoantigens
    • Emerging Technologies In PM

The Precision Medicine World Conference (PMWC), held annually in Silicon Valley, is coming back to North Carolina for its 2nd Conference back at Duke University on September 24-25, 2018.

PMWC 2018 Duke, the 15th installment of the conference, will spotlight the explosion of biomedical technologies, driving initiatives that enable the translation of precision medicine into direct improvements in health care.

 

    • Track 1 will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
      • Digital Phenotyping
      • Precision Public Health
      • Pharmacogenomics
      • The Microbiome
      • Rare Disease Diagnosis
      • Digital Health/Health and Wellness
      • Early Days of Life Sequencing
      • Diversity in Precision Medicine
      • Resilience
      • AI and Machine Learning
      • Gene Editing
      • Large Scale Bio-data Resources
        to Support Drug Development (PPPs)
      • Point-of Care Dx Platform
      • FDA Efforts to Accelerate PM
      • Implementation into Health Care Delivery
      • Next Gen. Workforce of PM
      • Immunotherapy
      • Robust Clinical Decision Support Tools
      • Creating Clinical Value with Liquid Biopsy
        ctDNA, etc.
      • Neoantigens
      • Emerging Technologies In PM
  • Track 2- PMWC 2018 Duke Showcase, will enable 15-minute company presentations on latest novel technologies. Apply to present here.
big data diagnostics session

Clinical Dx Showcase

crispr showcase

Emerging Therapeutics Showcase

NGS Showcase

Genomic Profiling Showcase

AI Showcase Session Image

AI and Data Sciences Showcase

  • Luminary and Pioneer Awards, honoring individuals who contributed, and continue to contribute, to the field of Precision Medicine
  • 500+ multidisciplinary attendees, from across the entire spectrum of healthcare, representing different types of companies, technologies, and medical centers with leadership roles in precision medicine

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