Dr. Compton-Phillips oversees Clinical Care for Providence St. Joseph Health, focused on creating high-value health outcomes for every individual seen. Key interest areas include developing cutting edge care through research, advanced access to care through innovation, highly reliable care processes through physician partnerships and systems design, and building the healthcare workforce of the future. Dr. Compton-Phillips has an extensive background in directing patient care programs and leading health care organizations to broad-based improvements. Read her full bio.

Interview with Amy Compton-Phillips of Providence St. Joseph Health

Q: Genomic medicine is entering more hospitals and bringing with it non-invasive technology that can be used to better target and treat diseases. What are some key milestones that contributed to this trend? What technological advancements are driving this change?

A: Genomic medicine is poised to move quickly from the research realm into integration with healthcare delivery, but there is always a time lapse between technology advances and what we do with those advances.

A reference point I often use is from the technology industry. Moore’s Law, defined by Intel co-founder Gordon Moore in the mid-1960s, stated that computing power would increase by double roughly every two years. That held true for 40-50 years, along with a steady decrease in the cost to use the technology. Then around 2007 there was an explosion of cultural developments in the form of the sharing economy – for examples, the introduction of sharing services such as Uber, AirBnb, Hadoop and the iPod. It took decades for society to catch up with what cheap computing technology had to offer and to start deploying it in transformative ways.

In the field of genomics, the Carlson curve for DNA sequencing and cost is occurring significantly faster than Moore’s Law from the computing revolution. When you put the data points together of 1). The reams of genetic data we’re discovering in DNA and 2). The decreasing cost of sequencing, then what you have is faster sequencing and lots of data to work with in new and transformative ways for better health. Our ability to learn from and embed knowledge from genomics into medicine will continue to accelerate at a dramatic pace, and the corresponding explosion of cultural developments is occurring much sooner than we saw with the technology revolution.

Q: What are some specific examples of how genomic medicine is improving healthcare?

A: As a healthcare provider that also does research and clinical trials, Providence St. Joseph Health has expertise in the cancer field.

If you look back 25 years ago, the cancer death rate was 210 out of 100,000. Today the rate is 160 per 100,000.

Through improved care for people diagnosed with cancer, including reducing risk factors, we’re helping save lives with personalized medicine and treatment. Along with many health systems, we’re changing the direction on cancer prognosis. We’re introducing hope for something that was once a life-ending scenario.

The drop in cancer death rate is a powerful example of changing population dynamics. It’s a sign something important is happening with precision medicine. The potential for all other health use cases is vast and is just starting to be tapped.

Q: What is required to see a more wide-spread adoption in the clinical sector?

A: I see four areas for continued development when it comes to adoption of genomic medicine in clinical practice.

First, it’s going back to the Carlson curve and continuing to lower costs, especially for testing. We haven’t hit the right price point yet for clinical must-haves in testing for what I think of as “—omics,” which is not just the genome but also the proteins in blood and symbiotic organisms in our guts and skin that together form each patient’s genomic universe.

Second, we need to insure that insurance coverage mirrors the clinical necessity of testing.

Third, we need clear data ownership rights for individuals over their genomic information and data security for anyone privileged enough to access information about a human’s genome.

Fourth, our capacity to learn rapidly from information needs to expand. This will require clinicians and data scientists working side by side, computing power and algorithms that help us learn faster. At Providence St. Joseph Health, we’ve been integrating data scientists into our clinical leadership team for several years now, building a new muscle memory for our health system.

Q: There are some obvious hurdles we need to overcome. Can you speak to the hurdles and how we can best address them as a community within the ecosystem of genomic medicine?

A: To me the three biggest and most immediate hurdles are around reimbursement, access to genetic counseling and integrating new genomic knowledge into medical practice.

Reimbursement for genomic testing needs to move to a less expensive price point, and we are looking to insurance companies to reimburse in more use cases. Right now it’s pretty limited to cancer instances. As we expand genomic testing beyond the cancer health scenario, we’ll need a mechanism in place to cover how testing will be reimbursed.

In general, new technology tends to be adopted by people with money. Over time the price comes down as the technology becomes a commodity, then more people have access to it. Today, genomic testing beyond cancer is still an early adopter or niche service for the “haves” in society.

Genetic counseling is an option for patients that was non-existent a few decades ago and it brings new territory to cover in the physician-patient relationship. It is important to understand what people want to know and to identify the potential of what can be done with information. Care teams will want to make sure testing only reveals what people want to know, similar to how we approach prenatal testing.

For example, in prenatal care, some expecting parents want to know the gender while others desire more insight on genetic risks like carrying genes for Alzheimer’s or Huntington’s disease. The clinical sector needs to work more with universities on identifying and articulating the risks and trade-offs of information, and how to communicate that to patients.

Finally, integrating genomic know-how into medical practice is daunting in some regards. The genome is unfathomably large, and expecting every physician to know every gene is not going to be realistic. We’ll need effective and simple systems to help doctors understand what genomic testing reveals.

Q: Is there anything else you would like to share - in the context of Genomic Medicine - with the PMWC audience?

A: As a clinician and health leader, the place I’d like to see the genomic community start focusing more is the treatment of disease. The power behind genomics is more about transformation in health and wellness. At Providence, we’re focused on what we call scientific wellness, which is identifying risk before a disease manifests and creating a personalized health plan that addresses behaviors that contribute to that disease. We could actually start preventing diseases from ever becoming manifest. To me, that is truly unlocking the power behind genomic testing.

Interview with Ken Bloom of Ambry Genetics

Q: Tell us more about your organization/company. What patient population are you serving and which services are you specializing in?

A: Ambry Genetics is a recognized leader in high quality complex genetic testing. We seek to find the genomic cause or contributors to rare diseases, abnormal phenotypes and hereditary disorders.

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Interview with Lee Pierce of Sirius Computer Solutions

Q: What is the state of big data and analytics in healthcare, and how to best use the reams of data available?

A: More than ever, Healthcare organizations are achieving measurable value through use of their data and analytics assets. There is more raw material available than ever to create value. This raw material is the data flowing from internal systems and applications and also from devices and systems external to healthcare organizations.

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Interview with Anita Nelsen of PAREXEL

Q: There are various new, emerging technologies that bring us closer towards a cure for life-threatening disorders such as cancer, HIV, or Huntington’s disease. Prominent examples include the popular gene editing tool CRISPR or new and improved cell and gene therapies. By when can we expect these new technologies being part of routine clinical care?

A: Today’s emerging technologies are making the promise of individualized treatment a reality.

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Interview with Ilan Kirsch of Adaptive Biotechnologies

Q: The Nobel Prize in Medicine was awarded recently to James Allison and Tasuku Honjo for their work on unleashing the body’s immune system to attack cancer, a breakthrough that has led to an entirely new class of drugs and brought lasting remissions to many patients who had run out of options. The Nobel committee hailed their accomplishments as establishing “an entirely new principle for cancer therapy.” What is your first-hand experience the impact that those new drugs had on patients?

A: For decades cancer was viewed as solely a cell-autonomous condition.

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BMS buys Celgene | Lilly buys Loxo Oncology – Does this Signal a Return to Strong Deal-Making Activities in 2019?

Bristol-Myers Squibb’s blockbuster $74B deal to buy Celgene creates an oncology powerhouse amid industrywide excitement about the rapidly evolving science and explosive growth of the sector. The agreement could signal a return to deal-making for the pharmaceutical industry in the $133B global oncology therapeutics market.

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Interview with Gini Deshpande of NuMedii

Q: What need is NuMedii addressing?

A: NuMedii, has been pioneering the use of Big Data, artificial intelligence (AI) and systems biology since 2010 to accelerate the discovery of precision therapies to address high unmet medical needs. Artificial Intelligence approaches are a natural fit to harness Big Data as they provide a framework to ‘train’ computers to recognize patterns and sift through vast amounts of new and existing genomic

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Interview with Minnie Sarwal of UCSF

Q: Genomic medicine is entering more hospitals and bringing with it non-invasive technology that can be used to better target and treat diseases. What are some key milestones that contributed to this trend?

A: Completion of complete sequence data from the human genome project, and the advances in proteomic, microRNA and epigenetic assays added a layer of pathway biology to the understanding of human diseases.

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Interview with Shidong Jia of Predicine

Q: Once sequencing has been validated as a clinical solution via trusted workflows, and coinciding with the technological developments driving costs lower, we can expect accelerated human genome profiling for clinical Dx. How soon, do you think, will we see accelerated growth and what can we expect?

A: We will see accelerated human genome profiling for clinical Dx in 2019 and the coming years as more biomarker-based cancer drugs are gaining approval.

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Interview with Iya Khalil of GNS Healthcare

Q: Artificial intelligence (AI) techniques have sent vast waves across healthcare, even fueling an active discussion of whether AI doctors will eventually replace human physicians in the future. Do you believe that human physicians will be replaced by machines in the foreseeable future? What are your thoughts?

A: I think that there’s a lot of speculation and uncertainty around AI, but I don’t foresee a time when we won’t need physicians.

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Interview with Ilya Michael Rachman of Immix Biopharma Inc.

Q: The Nobel Price in Medicine was awarded recently to James Allison and Tasuku for their work on unleashing the body’s immune system to attack cancer, a breakthrough that has led to an entirely new class of drugs and brought lasting remissions to many patients who had run out of options. The Nobel committee hailed their accomplishments as establishing “an entirely new principle for cancer therapy.” Besides CAR T-cell therapy what do you think next generation immunotherapies will look like to successfully combat cancer?

A: The next generation of immunotherapies will build on the insights discovered by immunologists like James Allison and Tasuku Honjo and extend them to modify the body’s response to tumors.

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Join me to Kick off PMWC Silicon Valley in the Santa Clara Convention Center, Focusing on Every Element of Precision Medicine

My team worked in collaboration with Bill Dalton, Kim Blackwell, Atul Butte / India Hook Barnard, Nancy Davidson and Sharon Terry to create a program that touches every component of precision medicine while bringing together all of its key stakeholders. Leading participating institutions including Stanford Health Care, UCSF, Duke Health, Duke University, John Hopkins University, University of Michigan and more will share their learnings and experiences and their successes and challenges, as they make precision medicine the new standard of care for all.

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Interview with Dominic Eisinger of Myriad RBM

Q: The Nobel Price in Medicine was awarded recently to James Allison and Tasuku for their work on unleashing the body’s immune system to attack cancer, a breakthrough that has led to an entirely new class of drugs and brought lasting remissions to many patients who had run out of options. The Nobel committee hailed their accomplishments as establishing “an entirely new principle for cancer therapy.” Besides CAR T-cell therapy what do you think next generation immunotherapies will look like to successfully combat cancer?

A: Next generation immunotherapies include CAR-Ts, TCRs, cancer vaccines, ADCs, bi-specific antibodies, and checkpoint inhibitors.

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2018 Year in Review Milestones: Stakeholder Partnerships Carving Precision Medicine’s Future

2018 has clearly been a year when significant opportunities intersected with strong partnerships to yield advancements. In particular, the clinical advancements that were realized are a testimony to stakeholders working together to deliver on promises affecting major aspects of precision medicine. 2018 has clearly been a year when significant opportunities intersected with strong partnerships to yield advancements.

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Interview with Lisa Alderson of Genome Medical

Q: Tell us a little bit about Genome Medical. What market need is Genome Medical addressing and how?

A: Genome Medical is a telegenomics company that is bridging the gap between available, genetic expertise and the clinical application of genomics.

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Interview with Nasir Bhanpuri of Virta Health

Q: What need is Virta Health addressing?

A: Virta Health delivers an evidence-based treatment to safely and sustainably reverse type 2 diabetes without the use of medications or surgery. In the U.S. alone, type 2 diabetes and prediabetes affects 115 million people, and the economic burden is well-over $300 billion and growing.

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Johns Hopkins
University Of Michigan

The Precision Medicine World Conference (PMWC), in its 17th installment, will take place in the Santa Clara Convention Center (Silicon Valley) on January 21-24, 2020. The program will traverse innovative technologies, thriving initiatives, and clinical case studies that enable the translation of precision medicine into direct improvements in health care. Conference attendees will have an opportunity to learn first-hand about the latest developments and advancements in precision medicine and cutting-edge new strategies and solutions that are changing how patients are treated.

See 2019 Agenda highlights:

  • Five tracks will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
    • AI & Data Science Showcase
    • Clinical & Research Tools Showcase
    • Clinical Dx Showcase
    • Creating Clinical Value with Liquid Biopsy ctDNA, etc.
    • Digital Health/Health and Wellness
    • Digital Phenotyping
    • Diversity in Precision Medicine
    • Drug Development (PPPs)
    • Early Days of Life Sequencing
    • Emerging Technologies in PM
    • Emerging Therapeutic Showcase
    • FDA Efforts to Accelerate PM
    • Gene Editing
    • Genomic Profiling Showcase
    • Immunotherapy Sessions & Showcase
    • Implementation into Health Care Delivery
    • Large Scale Bio-data Resources to Support Drug Development (PPPs)
    • Microbial Profiling Showcase
    • Microbiome
    • Neoantigens
    • Next-Gen. Workforce of PM
    • Non-Clinical Services Showcase
    • Pharmacogenomics
    • Point-of Care Dx Platform
    • Precision Public Health
    • Rare Disease Diagnosis
    • Resilience
    • Robust Clinical Decision Support Tools
    • Wellness and Aging Showcase

See 2019 Agenda highlights:

    • Five tracks will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
      • AI & Data Science Showcase
      • Clinical & Research Tools Showcase
      • Clinical Dx Showcase
      • Creating Clinical Value with Liquid Biopsy ctDNA, etc.
      • Digital Health/Health and Wellness
      • Digital Phenotyping
      • Diversity in Precision Medicine
      • Drug Development (PPPs)
      • Early Days of Life Sequencing
      • Emerging Technologies in PM
      • Emerging Therapeutic Showcase
      • FDA Efforts to Accelerate PM
      • Gene Editing / CRISPR
      • Genomic Profiling Showcase
      • Immunotherapy Sessions & Showcase
      • Implementation into Health Care Delivery
      • Large Scale Bio-data Resources to Support Drug Development (PPPs)
      • Microbial Profiling Showcase
      • Microbiome
      • Neoantigens
      • Next-Gen. Workforce of PM
      • Non-Clinical Services Showcase
      • Pharmacogenomics
      • Point-of Care Dx Platform
      • Precision Public Health
      • Rare Disease Diagnosis
      • Resilience
      • Robust Clinical Decision Support Tools
      • Wellness and Aging Showcase
  • Luminary and Pioneer Awards, honoring individuals who contributed, and continue to contribute, to the field of Precision Medicine
  • 2000+ multidisciplinary attendees, from across the entire spectrum of healthcare, representing different types of companies, technologies, and medical centers with leadership roles in precision medicine
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