AI and machine learning are poised to create a paradigm-shift in many areas of the healthcare sector. A recent Accenture report predicted that the AI/Machine Learning healthcare market could see an ELEVEN-FOLD INCREASE in value in less than a decade – growing from just $600 million in 2014 to $6.6 billion in the next three years, and creating $150 billion in annual savings for the US HEALTHCARE ECONOMY by 2026! It may not be overly ambitious to say that we are, in fact, on the brink of a revolution that will change every area of the healthcare and life science industries.

“Hiding within those mounds of data is knowledge that could change the life of a patient, or change the world.”

Atul Butte, M.D., Ph.D., Director, Institute for Computational Health Sciences, UCSF and Chair AI/Machine Learning Track, PMWC 2019 SV

The pharmaceutical industry is engaging AI to incorporate analytical solutions to accelerate drug discovery and development, the clinical sector looks to expedite diagnosis and treatments, the clinical trials sector hopes to better stratify patients based on their genetic make-up. With that, we see a shift towards prevention, personalization, and precision medicine. The PMWC 2019 Silicon Valley program traverses the various aspects of AI/Machine learning in healthcare which include:

  • An overview and discussion of their successes and failures
  • Applications in pre-clinical, drug design, discovery and prediction of drug development success
  • Challenges of applying AI on biomedical data
  • Ethical, privacy, and policy implications
  • Infrastructure, platform, and large data demands of AI and machine learning
  • FDA regulation of algorithms for decision support
  • AI in precision imaging to assist clinical decision-making and outcomes predictions
  • AI revolution in clinical trial design and patient selection
  • NGS knowledge extraction applications
  • Real-world evidence-based diagnostics and genomics-guided precision medicine

“We’re already seeing examples of progress, examples where an AI-enabled approach has brought novel, relevant insights into drug development – and I’m confident that we’ll see more and more of this as the technology teams robustify and add relevant drug development domain expertise.”

David A. Shaywitz, M.D., Ph.D., Senior Partner, Takeda Ventures, Inc. and “Big Data Revolution in Drug Development: Reality or Hype?” session chair

“Data-driven innovations are transforming every facet of our lives – most notably, healthcare and the life sciences. Big data and advanced analytics are powering the next great industrial revolution. The promise and potential are enormous: from novel medicines to better prediction of disease to selection of better interventions. Big data approaches have also been the subject of much hype and skepticism.”

Aris Baras, M.D. MBA, VP and Head, Regeneron Genetics Center

“Machine learning has demonstrated remarkable capabilities for solving hard problems, when given enough data; the synthesis of biology and technology has provided us with an array of amazing technologies to produce biological data at scale. Together, these open the door to a new paradigm for biological discovery and for tackling challenges in human health.”

Daphne Koller, PhD, Founder & CEO, Insitro

In the face of such rapid and ground-shaking changes, there will always be new challenges. When it comes to AI and Machine Learning, there are still legal, ethical and regulatory questions that remain unanswered.

“AI and machine learning show great potential to improve health and health care; however, the promise of AI won’t be achieved if we don’t attend to the ethical, legal and social implications at the front end and, continuously thereafter.”

Camille Nebeker, Ed.D, M.S., Director, Connected and Open Research Ethics, UCSD, School of Medicine

Looking forward to seeing many of you at the upcoming PMWC 2019 Silicon Valley conference on January 20-23 at the Santa Clara Convention Center, CA.

The PMWC team

Interview with Lingbing Zhang of Yinuoke Ltd

Q: The Nobel Prize in Medicine was awarded recently to James Allison and Tasuku for their work on unleashing the body’s immune system to attack cancer, a breakthrough that has led to an entirely new class of drugs and brought lasting remissions to many patients who had run out of options. The Nobel committee hailed their accomplishments as establishing “an entirely new principle for cancer therapy.” What is your first-hand experience the impact that those new drugs had on patients?

A: Although I don’t have first-hand experience with those new drugs, several of my friends asked me for suggestions because they know I have been studying cancer immunotherapy for 15 years.

Read More

Interview with Anton Iliuk of Tymora Analytical Operations

Q: What need is Tymora Analytical Operations addressing?

A: Virtually all of the current liquid biopsy assays are based on genomic information. But the active molecules in the body that are doing the work and undergoing changes during disease progression are actually proteins.

Read More

Interview with Pamela Munster of UCSF

Q: The Nobel Price in Medicine was awarded recently to James Allison and Tasuku for their work on unleashing the body’s immune system to attack cancer, a breakthrough that has led to an entirely new class of drugs and brought lasting remissions to many patients who had run out of options. The Nobel committee hailed their accomplishments as establishing “an entirely new principle for cancer therapy.” What is your first-hand experience the impact that those new drugs had on patients?

A: Immunotherapy has completely changed the lives of many patients with melanoma, lung cancer and other type of cancers with tumors that have historically been difficult to treat.

Read More

Interview with Stephane Budel, Partner of DeciBio Consulting

Q: NGS is enhancing patient care through improved diagnostic sensitivity and more precise therapeutic targeting. Prominent examples include cystic fibrosis and cancer. What other clinical areas NGS will most likely to change the standard-of-care in the near future?

A: NGS has most drastically impacted the standard of care in non-invasive prenatal testing (NIPT) and oncology.

Read More

Note from Dr. Kim Blackwell, PMWC 2019 SV Immunotherapy Track Chair to PMWC Admin

Hi PMWC, The Nobel Prize in Medicine was awarded on October 1st to Dr. James Allison (MD Anderson) and Dr. Tasuku Honjo (Kyoto University) for their work on unleashing the body’s immune system to attack cancer, a breakthrough that has led to an entirely new class of drugs and brought lasting remissions to many patients who had run out of options.

Read More

Interview with Bastian Greshake Tzovaras of Open Humans

Q: Patient healthcare data aggregation and analysis is seen as both the panacea for tremendous breakthroughs in precision medicine and as one of its biggest challenges. Are both true and how so?

A: The promises and challenges around personal health data aggregation are two sides of the same coin: There is definitely a lot of potential in the aggregating all these data, especially as we are now collecting so much data about ourselves.

Read More

Interview with Feng Zhang, PMWC 2019 Honoree- Neurobiologist Who Led the Development of Optogenetics and CRISPR

Q: What research are you or your lab focusing on and why, and what problem(s) are you trying to solve?

A: Our overall driving goal is to improve human health, and we do this largely through the development of new tools to study basic biology and the discovery of novel therapeutic approaches to treating human diseases.

Read More

Interview with Clifford Reid of Travera

Q: What need is Travera addressing?

A: The cancer community is suffering from a lack of biomarkers that match drugs to patients. The NCI-MATCH study reported in 2016 that fewer than 10% of cancer patients could be matched to a therapy.

Read More

Interview with Michael Abramoff of IDx

Q: Artificial intelligence (AI) techniques have sent vast waves across healthcare, even fueling an active discussion of whether AI doctors will eventually replace human physicians in the future. Do you believe that human physicians will be replaced by machines in the foreseeable future? What are your thoughts?

A: There will always be a need for human physicians, if only for the often raised issue of the need for human interaction.

Read More

Interview with Carl June, University of Pennsylvania, PMWC 2019 Honoree: The Driving Force Behind The First FDA Approved Gene Therapy – Kymriah

Q: The track theme is on the topic “How do we accelerate and deliver on the promise of cancer immunotherapy?” What are some key promises regarding immune-oncology, that we can build upon and translate into reality and how can we expedite delivery?

A: The use of the immune system to fight cancer holds a promise as a general solution to cancer therapy.

Read More

Questions for Sharon Terry, Genetic Alliance- PMWC 2019 Honoree

Q: You are the CEO of Genetic Alliance. What is your role as the CEO and why is this organization so important?

A: I actually try to avoid formal roles as CEO; instead, I practice showing up fully for our community: our staff and all of the organizations under our umbrella. I strive to hold the space for others to be fully themselves and meet their full potential.

Read More

Q&A with Itai Kela of Israel Innovation Authority

Q: Israel is known as a leader in hi-tech innovation. Can you tell us about some of the breakthrough companies in digital health and precision medicine?

A: The Israeli life sciences industry continues to grow and improve its global position. Israeli entrepreneurs’ ability to take advantage of the excellence in academic research, wide government support and innovative ecosystem, contributes to the industry’s success.

Read More

A Traverse of the Elements of AI/Machine Learning Across Healthcare

AI and machine learning are poised to create a paradigm-shift in many areas of the healthcare sector. A recent Accenture report predicted that the AI/Machine Learning healthcare market could see an ELEVEN-FOLD INCREASE in value in less than a decade

Read More

Jessica Mega of Verily Discusses AI in Healthcare

Q: Artificial intelligence (AI) techniques have sent vast waves across healthcare, even fueling an active discussion of whether AI doctors will eventually replace human physicians in the future. Do you believe that human physicians will be replaced by machines in the foreseeable future? What are your thoughts?

A: In addition to the science, the art of medical practice is a critical dimension of patient care and that part of the human experience can’t easily be replaced by AI.

Read More

Interview Questions For Gertjan Bartlema of Celularity, Inc.

Q: Artificial intelligence (AI) techniques have sent vast waves across healthcare, even fueling an active discussion of whether AI doctors will eventually replace human physicians in the future. Do you believe that human physicians will be replaced by machines in the foreseeable future? What are your thoughts?

A: In my opinion, physicians will not be replaced by machines in the foreseeable future.

Read More
Johns Hopkins
University Of Michigan

The Precision Medicine World Conference (PMWC), in its 16th installment, will take place in the Santa Clara Convention Center (Silicon Valley) on January 20-23, 2019. The program will traverse innovative technologies, thriving initiatives, and clinical case studies that enable the translation of precision medicine into direct improvements in health care. Conference attendees will have an opportunity to learn first-hand about the latest developments and advancements in precision medicine and cutting-edge new strategies and solutions that are changing how patients are treated.

Agenda highlights:

  • Five tracks will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
    • AI & Data Science Showcase
    • Clinical & Research Tools Showcase
    • Clinical Dx Showcase
    • Creating Clinical Value with Liquid Biopsy ctDNA, etc.
    • Digital Health/Health and Wellness
    • Digital Phenotyping
    • Diversity in Precision Medicine
    • Drug Development (PPPs)
    • Early Days of Life Sequencing
    • Emerging Technologies in PM
    • Emerging Therapeutic Showcase
    • FDA Efforts to Accelerate PM
    • Gene Editing
    • Genomic Profiling Showcase
    • Immunotherapy Sessions & Showcase
    • Implementation into Health Care Delivery
    • Large Scale Bio-data Resources to Support Drug Development (PPPs)
    • Microbial Profiling Showcase
    • Microbiome
    • Neoantigens
    • Next-Gen. Workforce of PM
    • Non-Clinical Services Showcase
    • Pharmacogenomics
    • Point-of Care Dx Platform
    • Precision Public Health
    • Rare Disease Diagnosis
    • Resilience
    • Robust Clinical Decision Support Tools
    • Wellness and Aging Showcase

Agenda highlights:

    • Five tracks will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
      • AI & Data Science Showcase
      • Clinical & Research Tools Showcase
      • Clinical Dx Showcase
      • Creating Clinical Value with Liquid Biopsy ctDNA, etc.
      • Digital Health/Health and Wellness
      • Digital Phenotyping
      • Diversity in Precision Medicine
      • Drug Development (PPPs)
      • Early Days of Life Sequencing
      • Emerging Technologies in PM
      • Emerging Therapeutic Showcase
      • FDA Efforts to Accelerate PM
      • Gene Editing / CRISPR
      • Genomic Profiling Showcase
      • Immunotherapy Sessions & Showcase
      • Implementation into Health Care Delivery
      • Large Scale Bio-data Resources to Support Drug Development (PPPs)
      • Microbial Profiling Showcase
      • Microbiome
      • Neoantigens
      • Next-Gen. Workforce of PM
      • Non-Clinical Services Showcase
      • Pharmacogenomics
      • Point-of Care Dx Platform
      • Precision Public Health
      • Rare Disease Diagnosis
      • Resilience
      • Robust Clinical Decision Support Tools
      • Wellness and Aging Showcase
  • Luminary and Pioneer Awards, honoring individuals who contributed, and continue to contribute, to the field of Precision Medicine
  • 2000+ multidisciplinary attendees, from across the entire spectrum of healthcare, representing different types of companies, technologies, and medical centers with leadership roles in precision medicine
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