Q: Olink has been rapidly growing its’ library of human protein biomarker assays. What are the popular clinical applications for your biomarker panels?

A: At the beginning of 2017, Olink launched 5 new panels (over 450 new targets) and expanded its offering to include around 1,000 validated protein assays. Another milestone reached this year is that there are now over 100 publications that cite using Olink panels, quite impressive considering the very first panel only came out in 2014. Olink’s ability to cast a broad proteomics net and isolate biomarker profiles for tailored approaches is being used for patient stratification, better understanding of pathophysiology of disease, predictive disease biomarkers, surrogates and optimizing wellness. We also see these types of applications applied across a range of clinical areas, including cardiovascular, neurological, inflammatory and metabolic diseases and oncology. You can see the latest list of these publications at www.olink.com/publications

Q: What are the benefits of Olink’s immune-oncology biomarker panel for researchers and clinicians working on immunotherapy-based cancer treatments?

A: It is the most comprehensive immune-oncology related protein panel out there, looking at 92 proteins simultaneously in only 1 uL of basically any sample type. Personalized oncology treatments are changing the way that we approach cancer therapy. The success of these therapeutic approaches will depend on an understanding of the underlying genetic mutations and the confirmatory proteomic profile of the cancer. Accessing non-invasive biomarkers, such as proteins present in blood or tissue, for the immuno-oncology area offer great potential benefits in helping to better understand the underlying pathophysiology, study therapeutic efficacy and stratify patients for clinical trials. Immune responses are complex and dynamic in nature, so monitoring changes at the protein level is likely to be important here. The immuno-oncology panel casts a relatively broad net, while enabling a targeted approach to include proteins involved in processes such as promotion and inhibition of tumor immunity, chemotaxis, vascular & tissue remodeling, apoptosis & cell killing and metabolism & autophagy.

Q: What are the benefits of the Olink Proximity Extension Assay technology?

A: PEA, or Proximity Extension Assay, is elegantly simple in its approach. PEA consists of pairs of antibodies linked to DNA oligos that, upon antibody binding on the protein, are brought into proximity, hybridize and can then be extended by a DNA polymerase, creating a new sequence that can be used as a template for measurement by qPCR.
Two antibodies must bind to the target protein for a signal to be generated, i.e dual recognition, which together with the fidelity of the unique PCR template generated, reduces non-specific binding and background. This results in increased sensitivity and specificity in a very broad dynamic range, compared to conventional immunoassays. PEA is truly scalable, whether you are measuring 92 protein targets from one of our panels, or narrowing the signature to a subset of protein assays. We currently have configured our assays to require only 1 microliter of sample per panel. The researcher can run nearly 1,000 protein assays with less than 20 uL of sample, that is quite a powerful tool, which will further enable scientific discovery.

Q: What do you see as the future of protein profiling for clinical utility?

A: Multiplexed proteomics has historically lagged behind genomics in the clinical biomarker arena, but this can be attributed mainly to the technologies available. It is probably fair to say that most people working with biomarkers and precision medicine see the essential role for protein biomarkers going forwards and many have been waiting for the right tools to do this. PEA can change that, truly enabling a proteomics technology that is already making a big impact in discovery applications in clinical research. Custom protein signatures are now being brought into the clinic for more tailored treatment strategies. We experience that signatures based on several proteins will be more powerful and robust than single proteins. Having a technology like PEA that is truly scalable may have some real benefits in potentially translating the findings from broad screening discovery to clinical utility of validated signatures enabling precision medicine.

Late breaking: Dawn Barry leaves Illumina to lead Luna DNA -Blockchain Disrupting Healthcare Industry

“Every individual holds a valuable piece of the puzzle to understand disease and health, and researchers are all in need of more data. Discovery is hindered by putting the majority of data into small silos. Breaking down data silos and bringing individuals together will more quickly aggregate enough samples to rise above the complexity of genomics and identify disease candidates.” – Dawn Barry, President and Co-Founder, Luna DNA

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Interview Dawn Barry the new President and Co-founder of Luna DNA

Q: In a sentence, what is Luna DNA going to do?

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JPM18: Edico Genome, Illumina, Invitae, Regeneron, Thermo Fisher Scientific,… and the list goes on

It’s been an announcement-packed JPMorgan Healthcare Conference in San Francisco this week!

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At PMWC 2018 Silicon Valley CMS Administrator Seema Verma Discusses the Future of Health Care

Genomics-based testing or new immunotherapies that revolutionize cancer care are changing how we approach disease…

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Interview with Dr. Frank Lee, Global Healthcare & Life Sciences Industry Leader at IBM; Chief Architect, IBM Reference Architecture for Genomics – Speaker at PMWC 2018 Silicon Valley

Q: As a pioneer in high performance architectures for genomic research what are the biggest challenges that you see clients dealing with as they invest in precision medicine initiatives?

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Q&A with Ira Mellman, PhD, Vice President, Cancer Immunology, Genentech – Speaker at PMWC 2018 Silicon Valley

Q: Immunotherapy is considered a huge game-changer and holds a lot of promises. Is the hype around immunotherapy justified? What are some of the exciting developments in the recent years?

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Interview with Atul Sharan, Co-founder and CEO, CellMax Life

Q: CellMax has developed non-invasive blood tests based on Circulating tumor cells CTC. How do you see these tests being adopted clinically?

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Q&A with Matthew Kane, Co-founder & CEO, Precision BioSciences – Speaker at PMWC 2018 Silicon Valley

Q: What are the benefits of the Precision BioSciences’ ARCUS genome editing platform and what makes it unique?

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Q&A with Jon Heimer, CEO, Olink Proteomics – Speaker at PMWC 2018 Silicon Valley

Q: Olink has been rapidly growing its’ library of human protein biomarker assays. What are the popular clinical applications for your biomarker panels?

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2017 Review: A Clear Paradigm Shift from a one-size-fits-all model to personalized healthcare

2017 saw technology innovations, new therapies and diagnostics, value-based healthcare, and clinical protocol advancements as huge drivers, moving the needle…

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Q&A with Peter Donnelly, Director, Wellcome Trust Centre for Human Genetics (Oxford) – Speaker at PMWC 2018 Silicon Valley

Q: How will genomics transform healthcare and how will it impact medicine? Beyond genetics and genomics what other data is relevant and why?

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PMWC Interview with Janusz Dutkowski, Ph.D., Co-founder & CEO, Data4Cure – Speaker at PMWC 2018 Silicon Valley

Q: What are some of the key unique ideas behind the Biomedical Intelligence Cloud? What contextual knowledge do you bring in?

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Q&A with Bob Terbrueggen, President & CEO, DxTerity – Speaker at PMWC 2018 Silicon Valley

Q: What are the challenges that the field of genomic research will face in the next five years?

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Q&A with Mark Kiel, CSO and Co-founder, Genomenon – Speaker at PMWC 2018 Silicon Valley

Q: What are the challenges facing clinical interpretation of NGS data today?

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Precision Medicine Jan 22-24th – learn from the experts at PMWC Silicon Valley 2018

Genomic Data Analysis / Next-Gen Sequencing, Immunotherapy / Cancer Care, & Artificial Intelligence / Machine Learning are all extensively covered at the conference, January 22-24

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University of Michigan

About us:
The Precision Medicine World Conference (PMWC), in its 13th installment, will take place in Silicon Valley on January 22-24, 2018. The program will traverse innovative technologies, thriving initiatives, and clinical case studies that enable the translation of precision medicine into direct improvements in health care. Conference attendees will have an opportunity to learn first-hand about the latest developments and advancements in precision medicine and cutting-edge new strategies and solutions that are changing how patients are treated.

Agenda highlights:

    • More than 70 sessions with 350+ thought-provoking, insightful talks that cover all facets of precision medicine
    • Four tracks will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
    • Immuno-oncology
    • Cancer and rare disease diagnostics
    • Biomarker and companion diagnostics
    • Big data approaches
    • NGS applications
    • AI and machine learning applications
    • Advancements in liquid biopsy applications
    • Wellness & Aging
    • CRISPR
    • The human microbiome
    • Infectious disease ID and monitoring
    • The importance of patient engagement
    • 3-D technologies
    • Updates on data and regulatory policies
    • Metabolomics in precision medicine
    • mHealth and Telehealth

About us:
The Precision Medicine World Conference (PMWC), in its 13th installment, will take place in Silicon Valley on January 22-24, 2018. The program will traverse innovative technologies, thriving initiatives, and clinical case studies that enable the translation of precision medicine into direct improvements in health care. Conference attendees will have an opportunity to learn first-hand about the latest developments and advancements in precision medicine and cutting-edge new strategies and solutions that are changing how patients are treated.

Agenda highlights:

    • More than 70 sessions with 350+ thought-provoking, insightful talks that cover all facets of precision medicine
    • Four tracks will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
        • Immuno-oncology
        • Cancer and rare disease diagnostics
        • Biomarker and companion diagnostics
        • Big data approaches
        • NGS applications
        • AI and machine learning applications
        • Advancements in liquid biopsy applications
        • Wellness & Aging
        • CRISPR
        • The human microbiome
        • Infectious disease identification and monitoring
        • The importance of patient engagement
        • 3-D technologies
        • Updates on data and regulatory policies
        • Metabolomics in precision medicine
        • mHealth and Telehealth

One track will be dedicated to the various aspects of the All of Us Research Program, while another session will focus on educating California’s legislators.

 

Confirmed thought leaders include:

Sir John Bell

Sir John Bell

Regius Professor of Medicine, Oxford University

sally-davies

Dame Sally Davies

Chief Medical Officer, Department of Health, UK Government

BLA00002-Elizabeth-Blackburn

Elizabeth Blackburn

Nobel Laureate, President, Salk Institute for Biological Studies

George-Sledge

George Sledge

Professor, Division Chief, Stanford University Medical Center

Jeffrey Bluestone

Jeffrey Bluestone

CEO and President, Parker Institute for Cancer Immunotherapy

Christopher Ianelli

Christopher Ianelli

Founder and Chief Executive Officer,  iSpecimen

Kenneth J. Pienta

Kenneth J. Pienta

Director, Brady Urological Institute, Johns Hopkins Medicine

Roy Beveridge

Roy Beveridge

Senior Vice President & Chief Medical Officer, Humana

Kimberly Blackwell

Kimberly Blackwell

Professor of Medicine, Assistant Prof. of Radiation Oncology, Duke Cancer Institute

Joshua Denny

Joshua Denny

Professor of Biomedical Informatics & Medicine, Vanderbilt University Medical Center

Edward S. Kim

Edward S. Kim

Chair, Solid Tumor and Investigational Therapeutics, Levine Cancer Institute

Howard L. McLeod

Howard L. McLeod

Medical Director, Personalized Medicine Institute, Moffitt Cancer Center

Lee Newcomer

Lee Newcomer

SVP, UnitedHealthcare Oncology and Genetics

Vinod Khosla

Vinod Khosla

Partner and Founder of Khosla Ventures

Troy Brennan

Troy Brennan

Executive VP & CMO, CVS Health

Ira Mellman

Ira Mellman

VP, Cancer Immunology, Genentech

Event Highlights

When
January 22, 2018 8:00am to January 24, 2018 5:00pm
Where
Computer History Museum
1401 N Shoreline Blvd
Mountain View, CA 94043
Cost
$1850 by January 19th, 2018
Registration
3-Day Access to Talks, Exhibition & Reception:
See Registration Details

Registration: PMWC Conferences

Silicon Valley Jan 22-24, 2018

65+ Sessions 4 Tracks
350+ Speaker lineup
Access to the exhibition
Breakfast & lunch refreshments
Networking App
Award Reception

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