Q: CellMax has developed non-invasive blood tests based on Circulating tumor cells CTC. How do you see these tests being adopted clinically?

A: As we all know, early detection is the only real cure for cancer. For most cancers the majority of patients are still diagnosed too late. We need convenient, affordable and accurate tests- that have the ability to detect cancer early- to meaningfully impact outcomes.

It has long been known that CTCs are the earliest sign of tumor cells in the blood-stream and finding them with a routine blood test would be an ‘ideal” screening test for early-detection of cancer. The unsolved technology problem is one of finding the proverbial needle in a haystack – 1-10 CTCs among a billion normal cells. At CellMax, after many years of extensive research we have found the needle. We have shown via multiple, prospective multi-year studies, published in peer-reviewed journals, that CellMax’s proprietary CTC CMx platform is highly sensitive, and globally affordable, for the early detection of cancer.
In 2016, we commercially launched our early-detection CTC blood tests.

CellMax’s CMx platform is also able to release these CTCs intact for further downstream interrogation of multiple clinically actionable analytes including DNA and Expression. This is very valuable for drug-development, as it allows us to enable Immuno-Oncology therapy development.

All this also means that CellMax is also able to offer to a patient diagnosed with cancer, a complete Liquid-Biopsy than from ctDNA alone, including PDL-1 protein expression detection for Immunotherapy eligibility.

Q: A lot of investment going into ctDNA technology. What role do you see CTCs playing?

A: In cancer, early detection is the only cure. Mostly cancer outcomes have changed only for those cancers that have a simple, routine, non-invasive affordable tests like PSA & Pap-smear. Early Detection Blood Tests have to be an order of magnitude cheaper than tests that rely on NGS using a single biomarker like ctDNA. CTCs – assuming the platform can find the “needle” – pass the affordability test.

On the disease side, a multi-biomarker approach is required. DNA is one of many actionable biomarkers in oncology. With CTCs, once the cancer cell is captured, it can be analyzed comprehensively for multiple actionable markers- DNA but also RNA and Methylation among others.

For ctDNA, the main enabler is Illumina and we see this rapidly becoming the lowest-common-denominator- if it isn’t already. Any lab with an Illumina sequencer and a ctDNA kit could claim to offer ctDNA based Liquid biopsy for advanced cancer. The challenge for ctDNA then is to do this cost-effectively, so anyone can access this test without needing insurance reimbursement. This is what we enable with our CTC CMx and NGS SMSeq platforms

Q: You have accredited labs in Asia and the US. How do you see differences in Asia and US?

A: Asia has several large population countries and there is significant need for an affordable early cancer detection. Locating in Asia allows us to offer fast turnaround for Asia but also the Middle-East.

In Asia tests are mostly self-pay. Any diagnostics – especially on the healthy screening side – that relies on insurance re-imbursement to be affordable is bound to fail. Used to be that Asia would wait for the US to first adopt – however nothing could be further from reality now. One common complaint in Asia is that many companies in the US have no clue about the price-points that work in Asia where there are no insurance companies to underwrite un-neccesarily over-priced tests. CellMax strategy from the beginning has been to offer globally affordable early cancer detection tests.

PMWC Michigan – Big Data in Action: Data-Driven Insights in the Clinic

We are excited to launch the first Precision Medicine World Conference (PMWC) at the University of Michigan June 6-7, 2018.

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Q: Your reputation for passion about engaging and empowering people precedes you. Can you please describe your role at the All of Us Research Program?

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Late breaking: Dawn Barry leaves Illumina to lead Luna DNA -Blockchain Disrupting Healthcare Industry

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Interview Dawn Barry the new President and Co-founder of Luna DNA

Q: In a sentence, what is Luna DNA going to do?

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JPM18: Edico Genome, Illumina, Invitae, Regeneron, Thermo Fisher Scientific,… and the list goes on

It’s been an announcement-packed JPMorgan Healthcare Conference in San Francisco this week!

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At PMWC 2018 Silicon Valley CMS Administrator Seema Verma Discusses the Future of Health Care

Genomics-based testing or new immunotherapies that revolutionize cancer care are changing how we approach disease…

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Interview with Dr. Frank Lee, Global Healthcare & Life Sciences Industry Leader at IBM; Chief Architect, IBM Reference Architecture for Genomics – Speaker at PMWC 2018 Silicon Valley

Q: As a pioneer in high performance architectures for genomic research what are the biggest challenges that you see clients dealing with as they invest in precision medicine initiatives?

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Q&A with Ira Mellman, PhD, Vice President, Cancer Immunology, Genentech – Speaker at PMWC 2018 Silicon Valley

Q: Immunotherapy is considered a huge game-changer and holds a lot of promises. Is the hype around immunotherapy justified? What are some of the exciting developments in the recent years?

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Interview with Atul Sharan, Co-founder and CEO, CellMax Life

Q: CellMax has developed non-invasive blood tests based on Circulating tumor cells CTC. How do you see these tests being adopted clinically?

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Q&A with Matthew Kane, Co-founder & CEO, Precision BioSciences – Speaker at PMWC 2018 Silicon Valley

Q: What are the benefits of the Precision BioSciences’ ARCUS genome editing platform and what makes it unique?

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Q&A with Jon Heimer, CEO, Olink Proteomics – Speaker at PMWC 2018 Silicon Valley

Q: Olink has been rapidly growing its’ library of human protein biomarker assays. What are the popular clinical applications for your biomarker panels?

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2017 Review: A Clear Paradigm Shift from a one-size-fits-all model to personalized healthcare

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University of Michigan

The 14th Precision Medicine World Conference (PMWC) will take place at the University of Michigan on June 6-7, 2018. This conference coincides with University of Michigan’s launch of a new Precision Health research initiative that integrates U of M’s strengths in Medicine, Engineering, Pharmacy, and Public Health. (hyperlink) This initiative combines biomedical expertise, big data, and the social sciences enabling a comprehensive approach to providing patients with tailored health solutions.

To support the University of Michigan’s goal to bring together leading researchers from across the university and the country to springboard this new and exciting research initiative, PMWC and U-M have agreed that the campus is an optimal location for the next conference. This forum will showcase practical content that helps close the knowledge gap among different sectors, thereby catalyzing cross-functional fertilization and collaboration to benefit both University of Michigan and PMWC attendees.

The program will feature innovative technologies, and analyze the success of already thriving initiatives and clinical case studies that enable the translation of precision medicine into direct improvements in health care. Conference attendees will have an opportunity to learn first-hand about the latest developments and advances in precision medicine and cutting-edge strategies and solutions that are fundamentally changing how patients are treated. This is reflected in the Program Theme: “Big Data in Action: Data-driven Insights in the Clinic”.

Agenda highlights:

    • More than 35 sessions with 100+ thought-provoking, insightful talks that cover all facets of precision medicine
    • Two tracks will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
    • Changing Pharmacogenomics
    • Community Setting Challenges
    • Patient Issues and Challenges
    • Legal and Ethical Issues
    • Integrating genomic data into EMRs
    • Emerging Technologies
    • Personalized Health Care Delivery
    • Personalized Modeling of Precision Health
    • NIH’s All of Us Study
    • Big Data in Action
    • Opioid Precision Health
    • Neurosciences
    • Big Data in the Clinic
    • Wellness and Aging
    • Epigenetics and Aging
    • Precision Cancer Therapy
    • Data Sharing in Translational Medicine
    • Economic and Socio-political Issues

The 14th Precision Medicine World Conference (PMWC) will take place at the University of Michigan on June 6-7, 2018. This conference coincides with University of Michigan’s launch of a new Precision Health research initiative that integrates U of M’s strengths in Medicine, Engineering, Pharmacy, and Public Health. (hyperlink) This initiative combines biomedical expertise, big data, and the social sciences enabling a comprehensive approach to providing patients with tailored health solutions.

To support the University of Michigan’s goal to bring together leading researchers from across the university and the country to springboard this new and exciting research initiative, PMWC and U-M have agreed that the campus is an optimal location for the next conference. This forum will showcase practical content that helps close the knowledge gap among different sectors, thereby catalyzing cross-functional fertilization and collaboration to benefit both University of Michigan and PMWC attendees.

The program will feature innovative technologies, and analyze the success of already thriving initiatives and clinical case studies that enable the translation of precision medicine into direct improvements in health care. Conference attendees will have an opportunity to learn first-hand about the latest developments and advances in precision medicine and cutting-edge strategies and solutions that are fundamentally changing how patients are treated. This is reflected in the Program Theme: “Big Data in Action: Data-driven Insights in the Clinic”.

Agenda highlights:

    • More than 35 sessions with 100+ thought-provoking, insightful talks that cover all facets of precision medicine
    • Two tracks will showcase sessions on the latest advancements in precision medicine which include, but are not limited to:
        • Changing Pharmacogenomics
        • Community Setting Challenges
        • Patient Issues and Challenges
        • Legal and Ethical Issues
        • Integrating genomic data into EMRs
        • Emerging Technologies
        • Personalized Health Care Delivery
        • Personalized Modeling of Precision Health
        • NIH’s All of Us Study
        • Big Data in Action
        • Opioid Precision Health
        • Neurosciences
        • Big Data in the Clinic
        • Wellness and Aging
        • Epigenetics and Aging
        • Precision Cancer Therapy
        • Data Sharing in Translational Medicine
        • Economic and Socio-political Issues

 

Confirmed thought leaders include:

Lee Hood

Lee Hood

Chief Science Officer, Providence Health

Eric Topol

Eric Topol

Chief Academic Officer, Scripps Health

Francis Collins

Francis Collins

Director of the National Institutes of Health (NIH)

Vicki L. Ellingrod

Vicki L. Ellingrod

Ass. Dir., Michigan Inst. for Clinical & Health Research

Goncalo Abecasis

Goncalo Abecasis

Chair, Department of Biostatistics, UM

Jeffrey Leiden

Jeffrey Leiden

Chairman, President and CEO, Vertex

Matthias Kretzler

Matthias Kretzler

Professor, Nephrology & Internal Medicine, UM

Arul Chinnaiyan

Arul Chinnaiyan

Professor of Pathology, Medical Institute, UM

David Ginsburg

David Ginsburg

Prof., Human Genetics; Investigator, UM

Steve Nelson

Steve Nelson

Chief Executive Officer, UnitedHealthcare

Gil Omenn

Gil Omenn

Dir., Comput. Med. & Bioinformatics Center, UM

Eric Lefkofsky

Eric Lefkofsky

Founder and CEO, Tempus

Steven Leeder

Steven Leeder

Dir., Clin. Pharmacology Children’s Mercy Hospital,(CMH)

Ariella Shikanov

Ariella Shikanov

Assistant Professor, Biomedical Engineering, UM

Lawrence Corey

Lawrence Corey

Presi. & Dir. Emeritus, Fred Hutch Cancer Research Cent.

Amir Dan Rubin

Amir Dan Rubin

President and CEO, One Medical

Isaac (Zac) Kohane

Isaac (Zac) Kohane

Professor of Pediatrics, Harvard University

Sachin Kheterpal

Sachin Kheterpal

Associate Professor, Anesthesiology, UM

Event Highlights

When
June 6, 2018 8:00am to June 7, 2018 5:00pm
Where
Ross School of Business
701 Tappan Ave
Ann Arbor, MI 48109
Cost
$550 by February 28th, 2018

Registration: PMWC Conferences

Michigan June 6-7, 2018

First PMWC In Midwest
2 Track Speaker Lineup
Access to the exhibition
Breakfast & lunch refreshments
Award Reception

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